OR13C8: A GPCR Targeted for Olfactory Disorders and Other Neurological Disorders
OR13C8: A GPCR Targeted for Olfactory Disorders and Other Neurological Disorders
Olfactory receptor family 13 (OR13) is a subfamily of G protein-coupled receptors (GPCRs) that play a crucial role in sensory function, particularly olfaction. OR13 is composed of four different genes: OR13A, OR13B, OR13C, and OR13D. In this article, we will focus on OR13C8, a GPCR that is expressed in the olfactory system and has been identified as a potential drug target in the field of olfactory disorders.
OR13C8 is a 19-kDa transmembrane protein that is expressed in the olfactory system, including the nasal epithelial cells, which line the nasal passages and conduct olfactory information to the brain. OR13C8 is a GPCR that is highly conserved in its amino acid sequence, with a predicted transmembrane spacing of 40 amino acids and a pI of 4.5. OR13C8 has a single transmembrane 伪-helical structure, which is characteristic of GPCRs.
OR13C8 is involved in the function of the olfactory system, specifically in the sense of smell. OR13C8 is a critical receptor for the neurotransmitter ethyl acetate (EAC), which is a key mediator of sensory input in the olfactory system. Ethyl acetate is released by the brain in response to the perception of sour or sweet smells, and it binds to OR13C8, leading to the activation of GPCRs and the transduction of sensory information to the brain.
OR13C8 has been shown to play a crucial role in the development and progression of several olfactory disorders, including neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. These disorders are characterized by the progressive loss of sensory function, including the loss of olfactory sensitivity.
In addition to its role in the olfactory system, OR13C8 has also been shown to play a critical role in the development and progression of other neurological disorders, including pain perception, anxiety, and depression. For example, studies have shown that OR13C8 is involved in the modulation of pain perception and that its activation can contribute to the development of chronic pain.
OR13C8 has also been shown to be involved in the modulation of anxiety and depression. Studies have shown that OR13C8 is involved in the modulation of anxiety-like behavior in animals and that its inhibition can alleviate these behaviors. Additionally, OR13C8 has been shown to be involved in the modulation of depression-like behavior in animals and that its activation can contribute to the development of these behaviors.
In conclusion, OR13C8 is a GPCR that is involved in the function of the olfactory system and has been shown to play a crucial role in the development and progression of several neurological disorders, including neurodegenerative diseases, pain perception, anxiety, and depression. Its potential as a drug target makes OR13C8 a promising target for the development of new treatments for these disorders. Further research is needed to fully understand the role of OR13C8 in the olfactory system and its potential as a drug target.
Protein Name: Olfactory Receptor Family 13 Subfamily C Member 8
Functions: Odorant receptor
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More Common Targets
OR13C9 | OR13D1 | OR13F1 | OR13G1 | OR13H1 | OR13J1 | OR13Z2P | OR14A16 | OR14A2 | OR14C36 | OR14I1 | OR14J1 | OR14L1P | OR1A1 | OR1A2 | OR1B1 | OR1C1 | OR1D2 | OR1D4 | OR1D5 | OR1E1 | OR1E2 | OR1E3 | OR1F1 | OR1F2P | OR1G1 | OR1I1 | OR1J1 | OR1J2 | OR1J4 | OR1K1 | OR1L1 | OR1L3 | OR1L4 | OR1L6 | OR1L8 | OR1M1 | OR1N1 | OR1N2 | OR1P1 | OR1Q1 | OR1S1 | OR1S2 | OR2A1 | OR2A1-AS1 | OR2A12 | OR2A14 | OR2A2 | OR2A20P | OR2A25 | OR2A4 | OR2A42 | OR2A7 | OR2A9P | OR2AE1 | OR2AG1 | OR2AG2 | OR2AJ1 | OR2AK2 | OR2AL1P | OR2AM1P | OR2AP1 | OR2AT4 | OR2B11 | OR2B2 | OR2B3 | OR2B6 | OR2C1 | OR2C3 | OR2D2 | OR2D3 | OR2F1 | OR2F2 | OR2G2 | OR2G3 | OR2G6 | OR2H1 | OR2H2 | OR2I1P | OR2J1 | OR2J2 | OR2J3 | OR2J4P | OR2K2 | OR2L13 | OR2L1P | OR2L2 | OR2L3 | OR2L5 | OR2L8 | OR2L9P | OR2M1P | OR2M2 | OR2M3 | OR2M4 | OR2M5 | OR2M7 | OR2Q1P | OR2S2 | OR2T1
