OR11H12: A Potential Drug Target and Biomarker for Multiple Diseases

OR11H12: A Potential Drug Target and Biomarker for Multiple Diseases

Olfactory receptor family 11 (OR11) is a subfamily of G protein-coupled receptors (GPCRs) that play a crucial role in sensory function, particularly olfaction. OR11H12 is a member of the OR11 subfamily and is expressed in the vomiting response of the fly. This protein has been identified as a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders.

The OR11H12 gene encodes a 154 amino acid protein that belongs to the superfamily of GPCRs. It consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain is involved in the formation of the protein-protein interaction and is responsible for the protein's stability and interactions with other molecules. The transmembrane domain is responsible for the protein's physical structure and function, as well as its rapid exchange with the intracellular domain. The intracellular domain is involved in the regulation of the protein's activity and stability.

OR11H12 is a member of the OR11 subfamily, which is characterized by the presence of a specific motif in the extracellular domain known as the \"OR11 family motif.\" This motif is composed of a leucine-rich region (LRR), a proline -rich region (PRR), and a leucine-rich repeat (LRR) at its C-terminus. The LRR is involved in the formation of the OR11 subfamily and is thought to play a role in the protein's stability and interactions with other molecules.

OR11H12 is expressed in a variety of tissues and cells, including the fly's vomiting response. This protein is involved in the regulation of the fly's taste perception and is thought to play a role in the development of taste preference. The expression of OR11H12 has also been observed in a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. This suggests that OR11H12 may be a potential drug target for these diseases.

In addition to its involvement in sensory function, OR11H12 has also been identified as a potential biomarker for several psychiatric disorders, including anxiety, depression, and schizophrenia. The expression of OR11H12 has been observed in the brains of individuals with these disorders and may be a useful diagnostic or therapeutic target.

OR11H12 has also been identified as a potential drug target for cancer. The expression of OR11H12 has been observed in a variety of cancer types, including breast, lung, and ovarian cancer. This suggests that OR11H12 may be a useful target for cancer treatment.

In conclusion, OR11H12 is a protein that has been identified as a potential drug target and biomarker for a variety of diseases. Its involvement in sensory function and its expression in neurodegenerative diseases, psychiatric disorders, and cancer make it an attractive target for research and development of new treatments. Further research is needed to fully understand the role of OR11H12 in these diseases and to develop effective treatments.

Protein Name: Olfactory Receptor Family 11 Subfamily H Member 12

Functions: Odorant receptor

The "OR11H12 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OR11H12 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

OR11H13P | OR11H2 | OR11H5P | OR11H6 | OR11H7 | OR11J2P | OR11J5P | OR11K2P | OR11L1 | OR11M1P | OR12D2 | OR12D3 | OR13A1 | OR13C2 | OR13C3 | OR13C4 | OR13C5 | OR13C8 | OR13C9 | OR13D1 | OR13F1 | OR13G1 | OR13H1 | OR13J1 | OR13Z2P | OR14A16 | OR14A2 | OR14C36 | OR14I1 | OR14J1 | OR14L1P | OR1A1 | OR1A2 | OR1B1 | OR1C1 | OR1D2 | OR1D4 | OR1D5 | OR1E1 | OR1E2 | OR1E3 | OR1F1 | OR1F2P | OR1G1 | OR1I1 | OR1J1 | OR1J2 | OR1J4 | OR1K1 | OR1L1 | OR1L3 | OR1L4 | OR1L6 | OR1L8 | OR1M1 | OR1N1 | OR1N2 | OR1P1 | OR1Q1 | OR1S1 | OR1S2 | OR2A1 | OR2A1-AS1 | OR2A12 | OR2A14 | OR2A2 | OR2A20P | OR2A25 | OR2A4 | OR2A42 | OR2A7 | OR2A9P | OR2AE1 | OR2AG1 | OR2AG2 | OR2AJ1 | OR2AK2 | OR2AL1P | OR2AM1P | OR2AP1 | OR2AT4 | OR2B11 | OR2B2 | OR2B3 | OR2B6 | OR2C1 | OR2C3 | OR2D2 | OR2D3 | OR2F1 | OR2F2 | OR2G2 | OR2G3 | OR2G6 | OR2H1 | OR2H2 | OR2I1P | OR2J1 | OR2J2 | OR2J3