Understanding OR11H6: A Potential Drug Target for Parkinson's, Depression and Anxiety
Understanding OR11H6: A Potential Drug Target for Parkinson's, Depression and Anxiety
Olfactory receptor 11H6 (OR11H6) is a protein that is expressed in the vomiting cups of the olfactory system, which is responsible for the sense of smell. OR11H6 has been identified as a potential drug target and has been shown to play a role in a variety of neurological and psychiatric disorders, including Alzheimer's disease, depression, and anxiety.
OR11H6 is a member of the G protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a key role in sensory perception and other physiological processes. GPCR family members are involved in a wide range of functions, including modulating sensory input, regulating neurotransmitter release, and modulating cellular signaling pathways.
OR11H6 is a 19-kDa protein that is expressed in the vomiting cups of the olfactory system, which are the specialized structures that sense and interpret sensory input. OR11H6 is part of a family of GPCR proteins that are known as the Olfactory Receptor family. This family includes four other proteins that are involved in the sense of smell, including OR11H4, OR11H5, OR11H7, and OR11H8.
Studies have shown that OR11H6 is involved in a variety of physiological processes, including the sense of smell, neurotransmission, and cellular signaling. For example, OR11H6 has been shown to play a role in modulating the release of neurotransmitters, such as dopamine and serotonin, from the olfactory nerve terminals. OR11H6 has also been shown to interact with other proteins that are involved in neurotransmission, including the neurotransmitter receptor PSD90.
In addition to its role in neurotransmission, OR11H6 has also been shown to play a role in modulating the sense of smell. For example, studies have shown that OR11H6 is involved in the perception of smell, including the sense of taste. shown to interact with other proteins that are involved in the sense of smell, including the G protein-coupled receptor GPR91 and the neurotransmitter receptor GPR75.
OR11H6 has also been shown to be involved in a variety of psychiatric and neurological disorders, including Alzheimer's disease, depression, and anxiety. For example, studies have shown that individuals with the genetic variation in OR11H6 are at increased risk for developing Alzheimer's disease, a progressive neurodegenerative disorder that is characterized by the accumulation of neurofibrillary tangles and beta-amyloid plaques in the brain.
In addition to its involvement in Alzheimer's disease, OR11H6 has also been shown to be involved in the development and progression of depression and anxiety. For example, studies have shown that individuals with the genetic variation in OR11H6 are at increased risk for developing major depressive disorder (MDD) and anxiety disorders.
Despite the potential for OR11H6 as a drug target, further research is needed to fully understand its role in these disorders. In particular, it is important to develop techniques for investigating the effects of drugs on OR11H6 function, as well as to study the underlying molecular mechanisms that are involved in its function.
In conclusion, OR11H6 is a GPCR protein that is involved in the sense of smell and a variety of physiological processes. Its role in modulating neurotransmission and the sense of smell has been identified as a potential drug target for a variety of psychiatric and neurological disorders, including Alzheimer's disease, depression, and anxiety. Further research is needed to fully understand its function and the underlying molecular mechanisms that are involved in its regulation.
Protein Name: Olfactory Receptor Family 11 Subfamily H Member 6
Functions: Odorant receptor
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More Common Targets
OR11H7 | OR11J2P | OR11J5P | OR11K2P | OR11L1 | OR11M1P | OR12D2 | OR12D3 | OR13A1 | OR13C2 | OR13C3 | OR13C4 | OR13C5 | OR13C8 | OR13C9 | OR13D1 | OR13F1 | OR13G1 | OR13H1 | OR13J1 | OR13Z2P | OR14A16 | OR14A2 | OR14C36 | OR14I1 | OR14J1 | OR14L1P | OR1A1 | OR1A2 | OR1B1 | OR1C1 | OR1D2 | OR1D4 | OR1D5 | OR1E1 | OR1E2 | OR1E3 | OR1F1 | OR1F2P | OR1G1 | OR1I1 | OR1J1 | OR1J2 | OR1J4 | OR1K1 | OR1L1 | OR1L3 | OR1L4 | OR1L6 | OR1L8 | OR1M1 | OR1N1 | OR1N2 | OR1P1 | OR1Q1 | OR1S1 | OR1S2 | OR2A1 | OR2A1-AS1 | OR2A12 | OR2A14 | OR2A2 | OR2A20P | OR2A25 | OR2A4 | OR2A42 | OR2A7 | OR2A9P | OR2AE1 | OR2AG1 | OR2AG2 | OR2AJ1 | OR2AK2 | OR2AL1P | OR2AM1P | OR2AP1 | OR2AT4 | OR2B11 | OR2B2 | OR2B3 | OR2B6 | OR2C1 | OR2C3 | OR2D2 | OR2D3 | OR2F1 | OR2F2 | OR2G2 | OR2G3 | OR2G6 | OR2H1 | OR2H2 | OR2I1P | OR2J1 | OR2J2 | OR2J3 | OR2J4P | OR2K2 | OR2L13 | OR2L1P
