ISCA1P1: A promising drug target and biomarker for the treatment of inflammatory diseases

Target Name: ISCA1P1

NCBI ID: G389293

ISCA1P1

Other Name(s): iron-sulfur cluster assembly 1 pseudogene 1 | ISCA1L | Iron-sulfur cluster assembly 1 pseudogene 1

ISCA1P1: A promising drug target and biomarker for the treatment of inflammatory diseases

Inflammatory diseases have a significant impact on human health, causing pain, damage to tissues, and leading to premature aging. One of the leading causes of chronic inflammation is the activation of the immune system, which leads to the production of pro-inflammatory cytokines. These cytokines can cause inflammation, pain, and damage to tissues, leading to the development of inflammatory diseases such as rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), and inflammatory bowel disease (IBD).

The ISCA1P1 gene has been identified as a promising drug target and biomarker for the treatment of inflammatory diseases. ISCA1P1 is a pseudogene that encodes a protein known as ISCA1P1, which plays a critical role in the regulation of inflammation and immune responses. ISCA1P1 has been shown to be involved in the formation of iron-sulfur clusters, which are highly reactive molecules that can participate in a variety of cellular processes, including inflammation, stress, and cellular signaling.

I. ISCA1P1 function and regulation

ISCA1P1 is a 21-kDa protein that is expressed in a variety of tissues and cells, including immune cells, epithelial cells, and nervous cells. It is a member of the superfamily of cytoskeletal proteins, which are involved in the regulation of cell shape and movement. ISCA1P1 is characterized by a unique N-terminal domain that contains a conserved nucleotide-binding oligomerization (NBO) domain, which is involved in the regulation of protein stability and function.

The NBO domain is responsible for the interaction of ISCA1P1 with DNA, allowing it to interact with specific genetic elements and regulate gene expression. This domain is also involved in the regulation of DNA replication and repair, as well as the regulation of protein stability and localization.

ISCA1P1 functions as a negative regulator of the NF-kappa-B signaling pathway, which is a critical pathway involved in the regulation of inflammation and immune responses. NF-kappa-B signaling is a complex process that involves the recruitment of various proteins to the nuclear membrane and the regulation of gene expression. ISCA1P1 functions as a negative regulator by binding to the p65尾 subunit of NF-kappa-B and preventing its phosphorylation and subsequent activation.

ISCA1P1 is also involved in the regulation of cellular stress responses, including the regulation of cell cycle progression and the detoxification of oxidative stress. ISCA1P1 has been shown to play a critical role in the regulation of cell cycle progression in response to stress, and it has been shown to interact with several stress-responsive genes, including the cyclic ADP-ribose synthase (CARPS) gene.

II. ISCA1P1 as a drug target

The ISCA1P1 gene has been shown to be involved in the regulation of a wide range of cellular processes, including inflammation, immune responses, and stress responses. As a result, ISCA1P1 has emerged as a promising drug target for the treatment of inflammatory diseases.

A. ISCA1P1 as a target for anti-inflammatory drugs

The ISCA1P1 gene has been shown to play a critical role in the regulation of pro-inflammatory cytokine production, which is a key step in the development of inflammatory diseases. ISCA1P1 has been shown to be involved in the formation of iron-sulfur clusters, which are highly reactive molecules that can participate in a variety of cellular processes, including inflammation, stress, and cellular signaling.

Therefore, ISCA1P1 has been shown to be an attractive target for the development of anti-inflammatory drugs. One of the leading compounds currently in development for the treatment of inflammatory diseases is a small molecule called TAS-4042, which is a selective inhibitor of

Protein Name: Iron-sulfur Cluster Assembly 1 Pseudogene 1

The "ISCA1P1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ISCA1P1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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