ISCA2: A Protein Potential Drug Target for Iron-Related Diseases

Target Name: ISCA2

NCBI ID: G122961

ISCA2

ISCA2: A Protein Potential Drug Target for Iron-Related Diseases

Iron-sulfur cluster assembly (ISCA) is a protein complex that plays a crucial role in the regulation of iron homeostasis in the human body. ISCA2, also known as transcript variant 1, is a protein that is expressed in high levels in the liver and other tissues and is involved in the assembly of the ISCA complex. The ISCA complex plays a vital role in the regulation of iron levels in the body and is a potential drug target for the treatment of iron-related diseases.

ISCA2 function

The ISCA2 protein is composed of four subunits, each of which has a distinct function in the assembly and function of the ISCA complex. The subunits include ISCA2, ISCA3, ISCA4, and ISCA5. These subunits are held together by disulfide bonds and are located in a parallel arrangement in the cell membrane.

The ISCA2 subunit is the key protein that interacts with the Fe2+ ion. ISCA2 has a unique structure that allows it to interact with Fe2+ ions in a specific way. This interaction is critical for the proper functioning of the ISCA complex. ISCA2 has been shown to play a role in the regulation of the levels of Fe2+ ions in the body and is involved in the transport of Fe2+ ions across the cell membrane.

The ISCA3 subunit is involved in the regulation of the assembly and disassembly of the ISCA complex. ISCA3 interacts with the ISCA2 subunit to prevent the formation of the ISCA complex and the subsequent disruption of the disulfide bonds that hold the subunits together.

The ISCA4 subunit is involved in the regulation of the stability of the ISCA complex. ISCA4 interacts with the ISCA2 subunit to promote the formation of the ISCA complex and to stabilize the complex against the dissociation of the subunits.

The ISCA5 subunit is involved in the regulation of the function of the ISCA complex. ISCA5 interacts with the ISCA2 subunit to modulate the activity of the complex and to regulate the levels of ISCA2 in the cell.

Drug targeting

The ISCA2 protein is a potential drug target for the treatment of iron-related diseases. ISCA2 has been shown to play a role in the regulation of the levels of Fe2+ ions in the body and is involved in the transport of Fe2+ ions across the cell membrane. Therefore, compounds that can modulate the activity of ISCA2 or its subunits may be useful for the treatment of iron-related diseases.

One class of compounds that have been shown to modulate the activity of ISCA2 is called thiostatins. Thiostatins are a type of molecule that can bind to various proteins, including ISCA2, and modulate their activity. Thiostatins have been shown to be effective in the treatment of iron-related diseases, such as hem iron deficiency and chronic iron deficiency.

Another class of compounds that have been shown to modulate the activity of ISCA2 are called tyrosine derivatives. Tyrosine derivatives are small molecules that can bind to various proteins, including ISCA2, and modulate their activity. Tyrosine derivatives have been shown to be effective in the treatment of iron-related diseases, such as hem iron deficiency and chronic iron deficiency.

Conclusion

In conclusion, ISCA2 is a protein that plays a crucial role in the regulation of iron homeostasis in the human body. The ISCA2 protein is involved in the assembly and function of the ISCA complex and is a potential drug target for the treatment of iron-related diseases. The modulation of the activity of ISCA2 by thiostatins and tyrosine derivatives suggests that these compounds may be useful

Protein Name: Iron-sulfur Cluster Assembly 2

Functions: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly

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