Potential Drug Target: Irak4 in Cancer, Neurodegenerative Diseases and Autoimmune Disorders

Target Name: IRAK4

NCBI ID: G51135

IRAK4

Potential Drug Target: Irak4 in Cancer, Neurodegenerative Diseases and Autoimmune Disorders

IRAK4 (Irak4) is a protein that is expressed in various tissues of the body, including the brain, heart, lungs, and gastrointestinal tract. It is a member of the irak family of proteins, which are known for their role in cell signaling.

Irak4 has been identified as a potential drug target due to its involvement in several cellular processes that are associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key functions of Irak4 is its role in the regulation of cell signaling pathways, particularly those that are involved in cell growth, differentiation, and survival. This protein has been shown to play a key role in the development and progression of several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Irak4 has been shown to promote the growth and survival of cancer cells, and it has been identified as a potential drug target for cancer treatment. Studies have shown that inhibiting the activity of Irak4 can lead to the growth of cancer cells in a cell culture model.

Irak4 is also involved in the regulation of cell migration, which is a critical process that allows cells to move and divide in the body. This protein has been shown to play a key role in the regulation of cell migration, and its activity has been linked to the development and progression of several diseases, including cancer.

Irak4 is also involved in the regulation of cell apoptosis, which is the process by which cells die and are removed from the body. This protein has been shown to play a key role in the regulation of cell apoptosis, and its activity has been linked to the development and progression of several diseases, including neurodegenerative diseases.

In addition to its role in cell signaling pathways, Irak4 has also been shown to play a key role in the regulation of cellular processes that are involved in the development and maintenance of tissues. This protein has been shown to promote the growth and survival of tissues, and its activity has been linked to the development and progression of several diseases, including cancer.

Given its involvement in so many cellular processes, it is not surprising that Irak4 has been identified as a potential drug target. Studies have shown that inhibiting the activity of Irak4 can lead to the inhibition of the development and progression of several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In conclusion, Irak4 is a protein that is involved in a wide range of cellular processes that are important for the development and maintenance of tissues. Its activity has been linked to the development and progression of several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, it is a potential drug target that could be targeted by small molecules or other therapeutic agents to treat these diseases. Further research is needed to fully understand the role of Irak4 as a drug target and to develop effective treatments for these diseases.

Protein Name: Interleukin 1 Receptor Associated Kinase 4

Functions: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections

The "IRAK4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IRAK4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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