Target Name: MCAT
NCBI ID: G27349
Review Report on MCAT Target / Biomarker Content of Review Report on MCAT Target / Biomarker
MCAT
Other Name(s): mitochondrial malonyltransferase | [acyl-carrier-protein] S-malonyltransferase | Malonyl-CoA:acyl carrier protein transacylase | Malonyl-CoA:acyl carrier protein transacylase, mitochondrial | MT | malonyl CoA:ACP acyltransferase (mitochondrial) | fabD | Malonyl-CoA:acyl-carrier-protein transacylase | Malonyl-CoA-acyl carrier protein transacylase, transcript variant 1 | Mitochondrial malonyltransferase | Malonyl-CoA-acyl carrier protein transacylase, mitochondrial | Malonyl coenzyme A-acyl carrier protein transacylase | [Acyl-carrier-protein] S-malonyltransferase | Malonyl transacylase | Malonyl transferase | MCT1 | Malonyl-CoA:ACP-SH transacylase | NET62 | Malonyl-CoA:AcpM transacylase | [Acyl-carrier-protein] malonyltransferase | MCT | Malonyl-CoA:ACP transacylase | MdcH | Malonyl-CoA-acyl carrier protein transacylase | Mitochondrial malonyl CoA:ACP acyltransferase | FASN2C | mitochondrial malonyl CoA:ACP acyltransferase | malonyl-CoA-acyl carrier protein transacylase | Malonyl-CoA/dephospho-CoA acyltransferase | Malonyl-CoA:[acyl-carrier-protein] S-malonyltransferase | FABD_HUMAN | FabD | MAT | Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (isoform a) | MCAT variant 1

MCAT: A Potential Drug Target and Biomarker for Fatty Acid Metabolism

Mitochondrial MalonylTransferase (MCAT) is a protein that plays a crucial role in the metabolism of fatty acids in the body. It is a key enzyme in the citric acid cycle, also known as the Krebs cycle or TCA cycle, which is a central metabolic pathway that generates energy in the form of ATP from the breakdown of fatty acids.

MCAT is expressed in most tissues of the body and is involved in the transfer of malonyl groups from the amino acid leucine to the carbon chain of the fatty acids. This transfer process is critical for the synthesis of fatty acids, including the ketones that are produced during the citric acid cycle.

MCAT is a potential drug target for several reasons. Firstly, it is a protein that is expressed in most tissues of the body, which makes it an attractive target for drug development. Secondly, MCAT is involved in the citric acid cycle, which is a critical pathway for the metabolism of fatty acids, making it an attractive target for drugs that target fatty acid metabolism.

Furthermore, MCAT is known to be a potent inhibitor of the citric acid cycle, which means that it can inhibit the production of fatty acids. This has been shown to have potential therapeutic applications, particularly in the treatment of obesity and other metabolic disorders.

MCAT is also a potential biomarker for the diagnosis and monitoring of fatty acid metabolism disorders. For example, MCAT is downregulated in individuals with certain metabolic disorders, such as obesity and non-alcoholic steatohepatitis (NASH), which are characterized by the accumulation of fat in the liver and other tissues. This downregulation of MCAT has been shown to be a potential diagnostic biomarker for these disorders.

In addition to its potential therapeutic and diagnostic applications, MCAT is also of interest to researchers because of its unique structure and mechanism of action. MCAT is a member of the superfamily of transferases, which includes enzymes that transfer amino acids to other proteins. This structure allows MCAT to transfer malonyl groups from the amino acid leucine to the carbon chain of the fatty acids.

The mechanism of action of MCAT is also unique because it uses a specific substrate, such as the amino acid leucine, to transfer the malonyl groups. This specificity allows MCAT to be a highly targeted enzyme and to be used as a drug or biomarker.

In conclusion, MCAT is a protein that plays a crucial role in the metabolism of fatty acids in the body and has the potential to be a drug target or biomarker. Its structure and mechanism of action make it an attractive target for drug development and research into fatty acid metabolism disorders. Further research is needed to fully understand the potential of MCAT as a therapeutic and diagnostic tool.

Protein Name: Malonyl-CoA-acyl Carrier Protein Transacylase

Functions: Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria

The "MCAT Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MCAT comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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