TRBV11-1: A Potential Drug Target and Biomarker (G28582)

Target Name: TRBV11-1

NCBI ID: G28582

TRBV11-1

Other Name(s): TRBV111 | TCRBV21S1 | T cell receptor beta variable 11-1 | TCRBV11S1

TRBV11-1: A Potential Drug Target and Biomarker

TRBV11-1, short for truncated recombinase RNA-binding protein 11-1, is a protein that is expressed in various tissues and cell types in the human body. It is a member of the RNA-binding protein family 11 (RBP11) and is characterized by its ability to bind to specific DNA sequences with high affinity.

The TRBV11-1 protein has been identified as a potential drug target due to its unique structure and its expressed levels in various tissues. TRBV11-1 has been shown to play a role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key reasons for the potential drug targeting of TRBV11-1 is its expression in multiple tissues and cells. TRBV11-1 is expressed in various tissues, including the brain, spinal cord, muscle, liver, and kidney. It is also expressed in various cell types, including epithelial cells, endothelial cells, and immune cells. This suggests that TRBV11-1 could be a useful biomarker for tracking the effectiveness of a potential drug.

Another reason for the potential drug targeting of TRBV11-1 is its unique structure. TRBV11-1 has a unique fold, which is characterized by a specific arrangement of its amino acid residues. This structure allows TRBV11-1 to bind to specific DNA sequences with high affinity and to participate in various cellular processes, including DNA replication, transcription, and gene regulation.

In addition to its unique structure, TRBV11-1 has also been shown to play a role in the development and progression of various diseases. For example, TRBV11-1 has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. It has also been shown to be involved in the development of cancer, including melanoma and lung cancer.

TRBV11-1 has also been shown to be involved in various cellular processes that are important for the maintenance of cellular health. For example, TRBV11-1 has been shown to play a role in regulating the expression of genes that are involved in cell growth, differentiation, and apoptosis. It has also been shown to play a role in regulating the expression of genes that are involved in inflammation and immune response.

In conclusion, TRBV11-1 is a protein that has potential as a drug target due to its unique structure and its expressed levels in various tissues and cells. Its potential drug targeting may be based on its ability to bind to specific DNA sequences with high affinity and its role in the development and progression of various diseases. Further research is needed to fully understand the potential drug targeting of TRBV11-1 and to develop effective treatments for various diseases associated with this protein.

Protein Name: T Cell Receptor Beta Variable 11-1

Functions: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

The "TRBV11-1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRBV11-1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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