GTF2I: A Scaffold Protein Involved in Cell Signaling, Tissue Repair and Cell Survival

Target Name: GTF2I

NCBI ID: G2969

GTF2I

GTF2I: A Scaffold Protein Involved in Cell Signaling, Tissue Repair and Cell Survival

Bruton tyrosine kinase-associated protein 135 (GTF2I) is a protein that is expressed in various tissues, including the brain, heart, and kidneys. It is a member of the Bruton tyrosine kinase family, which is a group of transmembrane proteins that play important roles in cell signaling. GTF2I is involved in a variety of physiological processes, including cell proliferation, differentiation, and survival.

One of the key functions of GTF2I is its role in cell signaling. GTF2I is a scaffold protein that can interact with various signaling molecules, including tyrosine kinases. These interactions allow GTF2I to play a role in the regulation of cellular signaling pathways, including the T cell signaling pathway.

In addition to its role in cell signaling, GTF2I is also involved in the regulation of cellular processes that are important for tissue repair and regeneration. For example, GTF2I has been shown to play a role in the regulation of neurogenesis, the process by which new neurons are produced in the brain.

Another function of GTF2I is its role in the regulation of cellular interactions with the extracellular matrix (ECM). GTF2I is involved in the formation of tight junctions, which are a type of cell-cell adhesion that helps to maintain the integrity of the ECM.

GTF2I is also involved in the regulation of cellular processes that are important for cell survival. For example, GTF2I has been shown to play a role in the regulation of apoptosis, the process by which cells die as a result of various stimuli.

In conclusion, GTF2I is a protein that is involved in a variety of important cellular processes. Its role in cell signaling, tissue repair and regeneration, and cell survival makes GTF2I an attractive potential drug target or biomarker. Further research is needed to fully understand the functions of GTF2I and its potential as a drug or biomarker.

Protein Name: General Transcription Factor IIi

Functions: Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation

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•   general information;
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•   protein biological mechanisms;
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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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