PKN1: A Potential Drug Target and Biomarker for Cell Signaling Pathways

Target Name: PKN1

NCBI ID: G5585

PKN1

PKN1: A Potential Drug Target and Biomarker for Cell Signaling Pathways

Protein kinase N1 (PKN1) is a protein that plays a critical role in cell signaling pathways. It is a non-catalytic protein that is involved in various cellular processes such as cell growth, differentiation, and survival. PKN1 is a protein that has been identified as a potential drug target and has been the subject of intense research in recent years. In this article, we will explore PKN1, its functions, potential drug targets, and its role in disease.

PKN1 functions

PKN1 is a protein that is expressed in various tissues of the body, including muscle, heart, brain, and kidney. It is involved in various cellular processes such as cell signaling pathways. PKN1 is a non-catalytic protein that uses its unique structure to activate and regulate protein kinases.

PKN1 has been shown to be involved in cell signaling pathways that are critical for cellular growth, differentiation, and survival. For example, PKN1 has been shown to be involved in the regulation of cell proliferation, cell migration, and cell survival. PKN1 has also been shown to be involved in the regulation of cell signaling pathways that are critical for neural development and function.

PKN1 as a drug target

PKN1 has been identified as a potential drug target due to its involvement in various cellular processes that are critical for human health and disease. PKN1 has been shown to be involved in the regulation of cell signaling pathways that are critical for cancer, neurodegenerative diseases, and cardiovascular diseases.

PKN1 has been shown to be involved in the regulation of cell signaling pathways that are critical for the development and progression of various cancers, including breast, ovarian, and prostate cancers. PKN1 has also been shown to be involved in the regulation of cell signaling pathways that are critical for the development and progression of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

PKN1 has also been shown to be involved in the regulation of cell signaling pathways that are critical for cardiovascular diseases, including heart failure, hypertension, and stroke. PKN1 has been shown to be involved in the regulation of cell signaling pathways that are critical for the development and progression of cardiovascular diseases.

PKN1 as a biomarker

PKN1 has also been shown to be a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. PKN1 has been shown to be expressed in various tissues of the body and can be used as a biomarker for these diseases.

PKN1 has been shown to be involved in the regulation of cell signaling pathways that are critical for the development and progression of cancer. PKN1 has been shown to be involved in the regulation of cell signaling pathways that are critical for the development and progression of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. PKN1 has also been shown to be involved in the regulation of cell signaling pathways that are critical for cardiovascular diseases, including heart failure, hypertension, and stroke.

Conclusion

In conclusion, PKN1 is a protein that plays a critical role in cell signaling pathways. It is a non-catalytic protein that uses its unique structure to activate and regulate protein kinases. PKN1 has been shown to be involved in various cellular processes that are critical for human health and disease, including cancer, neurodegenerative diseases, and cardiovascular diseases. As a result, PKN1 has been identified as a potential drug target and has been the subject of intense research in recent years. Further research is needed to fully understand the functions of PKN1 and its potential as a drug and biomarker.

Protein Name: Protein Kinase N1

Functions: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro

The "PKN1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PKN1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets