PKP4: A Protein Involved in Cell Signaling and Cytoskeletal Organization

Target Name: PKP4

NCBI ID: G8502

PKP4

PKP4: A Protein Involved in Cell Signaling and Cytoskeletal Organization

PKP4 (Catenin 4) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a member of the superfamily of actinin-associated proteins (SAP), which are involved in cell signaling and cytoskeletal organization. While the exact function of PKP4 is not yet well understood, research has shown that it plays a role in several physiological processes, including cell migration, invasion, and metastasis.

One of the key functions of PKP4 is its role in cell signaling. It is involved in the regulation of several intracellular signaling pathways, including the TGF-β pathway, which is involved in cell growth, differentiation, and survival. PKP4 has been shown to play a negative role in the TGF-β pathway, by inhibiting the activity of the transcription factor SMAD2. This negative regulation of SMAD2 allows PKP4 to prevent excessive cell proliferation and promote cell differentiation.

Another function of PKP4 is its role in cell adhesion. It is involved in the formation of tight junctions, which are specialized junctions that are responsible for maintaining the integrity of the intercellular space. PKP4 has been shown to play a role in the regulation of tight junction formation by interacting with the protein Zonl1. This interaction between PKP4 and Zonl1 allows PKP4 to regulate the movement of proteins into the cell, which is important for maintaining the integrity of the tight junction.

In addition to its role in cell signaling and adhesion, PKP4 is also involved in the regulation of cell migration and invasion. It has been shown to play a role in the regulation of the migration of cancer cells through the regulation of the migration protein ACF2. PKP4 has also been shown to play a role in the regulation of cell invasion, by interacting with the protein N-cadherin. This interaction between PKP4 and N-cadherin allows PKP4 to regulate the movement of cells into new tissues.

The potential drug target for PKP4 is its role in cell signaling and its involvement in several physiological processes. PKP4 has been shown to play a negative role in the TGF-β pathway, which is involved in cell growth, differentiation, and survival. It is also involved in the regulation of cell adhesion and the regulation of cell migration and invasion. This suggests that PKP4 may be a useful drug target for the treatment of various diseases, including cancer.

In conclusion, PKP4 is a protein that is expressed in various tissues throughout the body, and it plays a role in several physiological processes, including cell signaling, adhesion, and migration. The potential drug target for PKP4 is its role in the regulation of cell signaling and its involvement in the TGF-β pathway. Further research is needed to fully understand the function of PKP4 and its potential as a drug target.

Protein Name: Plakophilin 4

Functions: Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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