PKN2: A Protein Involved in Cellular Processes and Disease Development

Target Name: PKN2

NCBI ID: G5586

PKN2

PKN2: A Protein Involved in Cellular Processes and Disease Development

PKN2 (Cardiolipin-activated protein kinase) is a protein that is expressed in various tissues throughout the body, including the heart, lungs, kidneys, and liver. It is a member of the protein kinase superfamily and is involved in the regulation of various cellular processes, including cell signaling, inflammation, and stress responses. PKN2 has also been implicated in the development and progression of various diseases, including heart disease, cancer, and neurodegenerative disorders. As a result, PKN2 has become a promising drug target for researchers to explore for new treatments and biomarkers.

The protein kinase superfamily is a large family of enzymes that are involved in the regulation of protein function. These enzymes use a common mechanism to achieve their catalytic activity, which involves the recruitment of a phosphate group to the protein's active site. PKN2 is a member of this superfamily and is characterized by its unique catalytic mechanism. Unlike other protein kinases, PKN2 does not require a nucleotide to activate its activity. Instead, it is activated by the presence of cardiolipin, which is a lipid molecule that is derived from the blood lipids.

PKN2 is involved in the regulation of various cellular processes, including cell signaling, inflammation, and stress responses. One of its most well-studied functions is its role in the regulation of angiogenesis, the process by which new blood vessels are formed in the body. PKN2 has been shown to play a negative role in the regulation of angiogenesis and has been linked to the development of various diseases, including heart disease and cancer.

In addition to its role in angiogenesis, PKN2 is also involved in the regulation of inflammation and stress responses. It has been shown to play a positive role in the regulation of inflammation and has been linked to the development of various inflammatory diseases, including cancer and neurodegenerative disorders. PKN2 has also been shown to play a negative role in the regulation of stress responses and has been linked to the development of stress-related diseases, including heart disease and cancer.

As a result of its involvement in these processes, PKN2 has become a promising drug target for researchers to explore for new treatments and biomarkers. Studies have shown that inhibiting the activity of PKN2 has been effective in treating various diseases, including heart disease, cancer, and neurodegenerative disorders. Additionally, PKN2 has also been shown to be a potential biomarker for several diseases, including heart disease, cancer, and neurodegenerative disorders.

In conclusion, PKN2 is a protein that is involved in the regulation of various cellular processes in the body. It has been shown to play a negative role in the regulation of angiogenesis, inflammation, and stress responses, and has been linked to the development of various diseases. As a result, PKN2 has become a promising drug target for researchers to explore for new treatments and biomarkers. Further studies are needed to fully understand the role of PKN2 in the regulation of cellular processes and its potential as a drug target.

Protein Name: Protein Kinase N2

Functions: PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747)

The "PKN2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PKN2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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