ITGAM's Role in Disease Development (G3684)

Target Name: ITGAM

NCBI ID: G3684

ITGAM

ITGAM's Role in Disease Development

ITGAM (ITGAM-alpha polypeptide) is a protein that is expressed in various tissues of the body, including the lungs, heart, kidneys, and intestine. It is a member of the ITGAM family of proteins, which are characterized by the presence of a specific N- terminal peptide that is involved in the formation of a protein-protein complex. While ITGAM is not a well-known protein by itself, its presence and function have been studied extensively in the context of various diseases, including cancer, cardiovascular disease, and neurodegenerative diseases.

Diseases associated with ITGAM

ITGAM has been implicated in the development and progression of several diseases, including cancer, cardiovascular disease, and neurodegenerative diseases.

1. Cancer

Studies have shown that ITGAM is often overexpressed or expressed at higher levels than in healthy tissues in a variety of cancer types, including lung, breast, and colorectal cancers. High ITGAM expression has been associated with poor prognosis and increased cancer recurrence. Additionally, ITGAM has been shown to play a role in the development of cancer stem cells, which are a source of cancer recurrence.

2. Cardiovascular disease

ITGAM has also been associated with the development and progression of cardiovascular disease. Studies have shown that ITGAM is expressed at higher levels in the hearts and lungs of individuals with cardiovascular disease compared to those without the disease. Additionally, ITGAM has been shown to play a role in the formation of blood clots, which can contribute to the development of cardiovascular disease.

3. Neurodegenerative diseases

ITGAM has also been implicated in the development and progression of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Studies have shown that ITGAM is expressed at higher levels in the brains of individuals with neurodegenerative diseases compared to those without the disease. Additionally, ITGAM has been shown to play a role in the formation of neurofibrillary tangles and neuroglial cells, which are thought to contribute to the development and progression of neurodegenerative diseases.

4. Other diseases

ITGAM has also been implicated in the development and progression of other diseases, including autoimmune diseases, autoinflammatory diseases, and diseases of the respiratory system.

Conclusion

In conclusion, ITGAM is a protein that has been implicated in the development and progression of a variety of diseases. While more research is needed to fully understand its role in these diseases, its presence and function are clear and its potential as a drug target or biomarker is significant. As research continues to develop, ITGAM is likely to become a valuable tool for the diagnosis and treatment of a wide range of diseases.

Protein Name: Integrin Subunit Alpha M

Functions: Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity)

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•   expression level;
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