KRT18P31: A Potential Drug Target and Biomarker (G646723)

KRT18P31: A Potential Drug Target and Biomarker

Keratin 18 (K18) pseudogene 31 (KRT18P31) is a non-coding DNA sequence located on chromosome 18q21. It has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The K18 gene is a member of the keratin gene family, which is responsible for the production of the protein keratin, which is a structural component of hair, nails, and other feathers. In humans, the K18 gene encodes a 224 amino acid protein that is predominantly composed of alpha-helical structure.

KRT18P31 has been shown to be involved in various cellular processes, including cell growth, differentiation, and inflammation. It has been shown to play a role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the most significant studies that has investigated the potential drug target of KRT18P31 was a mouse model of neurodegenerative disease. In this study, researchers found that overexpression of KRT18P31 in mouse neural stem cells led to the development of neurodegenerate symptoms, including decreased brain volume , increased neurofilament tangles, and reduced neurotransmitter release. These findings suggest that KRT18P31 may be a potential drug target for neurodegenerative diseases.

Another study that has investigated the potential drug target of KRT18P31 was a cancer model. In this study, researchers found that KRT18P31 was overexpressed in various cancer cell types, including breast, lung, and ovarian cancer. They also found that KRT18P31 was involved in the development and progression of cancer, and that inhibition of KRT18P31 may be a potential cancer therapeutic approach.

In addition to its potential drug target and biomarker properties, KRT18P31 has also been shown to have potential utility as a diagnostic tool. The K18 gene has been used to develop a PCR-based diagnostic assay for the detection of skin cancer. In this assay, researchers found that the K18 gene was overexpressed in skin cancer cells, and that this overexpression was associated with the development of cancer.

Overall, the potential drug target and biomarker properties of KRT18P31 make it an intriguing candidate for further investigation. Further studies are needed to fully understand its role in disease and to develop safe and effective drugs that target KRT18P31.

Protein Name: Keratin 18 Pseudogene 31

The "KRT18P31 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KRT18P31 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

KRT18P33 | KRT18P34 | KRT18P4 | KRT18P40 | KRT18P41 | KRT18P42 | KRT18P44 | KRT18P48 | KRT18P49 | KRT18P5 | KRT18P50 | KRT18P51 | KRT18P55 | KRT18P59 | KRT18P6 | KRT18P62 | KRT19 | KRT19P2 | KRT19P3 | KRT2 | KRT20 | KRT222 | KRT23 | KRT24 | KRT25 | KRT26 | KRT27 | KRT28 | KRT3 | KRT31 | KRT32 | KRT33A | KRT33B | KRT34 | KRT35 | KRT36 | KRT37 | KRT38 | KRT39 | KRT4 | KRT40 | KRT42P | KRT5 | KRT6A | KRT6B | KRT6C | KRT7 | KRT7-AS | KRT71 | KRT72 | KRT73 | KRT73-AS1 | KRT74 | KRT75 | KRT76 | KRT77 | KRT78 | KRT79 | KRT8 | KRT80 | KRT81 | KRT82 | KRT83 | KRT84 | KRT85 | KRT86 | KRT87P | KRT89P | KRT8P10 | KRT8P11 | KRT8P12 | KRT8P14 | KRT8P16 | KRT8P17 | KRT8P18 | KRT8P22 | KRT8P23 | KRT8P25 | KRT8P26 | KRT8P29 | KRT8P3 | KRT8P33 | KRT8P36 | KRT8P37 | KRT8P39 | KRT8P41 | KRT8P44 | KRT8P45 | KRT8P46 | KRT8P47 | KRT8P48 | KRT8P49 | KRT8P5 | KRT8P7 | KRT8P8 | KRT8P9 | KRT9 | KRT90P | KRTAP1-1 | KRTAP1-3