KRT4: A Key Regulator of Cell-Cell Adhesion and Cancer (G3851)

Target Name: KRT4

NCBI ID: G3851

KRT4

KRT4: A Key Regulator of Cell-Cell Adhesion and Cancer

KRT4 (K2C4_HUMAN) is a gene that encodes a protein known as KRT4, which is a key regulator of cell-cell adhesion. The KRT4 protein plays a crucial role in maintaining the integrity of tissues and has been implicated in a number of diseases, including cancer. As a result, KRT4 has emerged as a promising drug target and biomarker for a variety of diseases.

The KRT4 gene was identified in the late 1990s as a potential gene for cancer. This was based on the fact that many cancer cells had increased levels of the KRT4 protein compared to their surrounding tissue. The KRT4 protein is involved in the regulation of cell-cell adhesion, which is the process by which cells stick together to form tissues and organs. In cancer, this process can often go out of control, leading to the development of tumors.

Since its identification, research has focused on understanding the functions of the KRT4 protein and how it contributes to the development and progression of cancer. This research has led to the conclusion that KRT4 is a key regulator of cell-cell adhesion and that its levels are often elevated in cancer cells.

One of the key functions of the KRT4 protein is its role in the regulation of cadherins, a family of transmembrane proteins that play a central role in cell-cell adhesion. Cadherins are responsible for holding cells together and are involved in many important processes in the body, including cell growth, differentiation, and cancer progression.

Research has shown that KRT4 is involved in the regulation of cadherin function by affecting the stability and localization of cadherins. This is done by the KRT4 protein, which acts as a scaffold to recruit cadherins to the plasma membrane and then modulates their stability to ensure that they remain in place.

Another function of the KRT4 protein is its role in the regulation of cell-cell adhesion. This is done by the KRT4 protein, which acts as a receptor for cadherins and other cell-cell adhesion molecules. This allows the KRT4 protein to interact with these molecules and regulate their activity.

In addition to its role in cell-cell adhesion, the KRT4 protein has also been shown to be involved in the regulation of many other processes in the body. For example, research has shown that KRT4 is involved in the regulation of cell migration, which is the movement of cells from one location to another in the body.

The KRT4 protein has also been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels grow in the body. This is done by the KRT4 protein, which acts as a regulator of the growth and differentiation of blood vessels.

In conclusion, the KRT4 protein is a key regulator of cell-cell adhesion and has been implicated in a number of diseases, including cancer. As a result, KRT4 has emerged as a promising drug target and biomarker for a variety of diseases. Further research is needed to fully understand the functions of the KRT4 protein and its potential as a drug.

Protein Name: Keratin 4

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