KRT18P40: A Potential Drug Target and Biomarker (G390904)

KRT18P40: A Potential Drug Target and Biomarker

Keratin is a protein that plays a crucial role in the structure and function of hair and nails. It is composed of several types, including alpha, beta, gamma, delta, and epsilon, which are responsible for different aspects of the protein. While all of these types of keratin share some similar features, they differ in their length and the specific sequence of their amino acid building blocks.

One of the most interesting aspects of keratin is its ability to be modified and cross-linked with other proteins. This process is known as cross-linking, and it allows thekeratin to form a strong and durable bond with the surrounding tissue. In the case of KRT18P40, this protein is known to be modified with a tyrosine residue, which is a common modification that allows it to interact with other proteins and participate in signaling pathways.

KRT18P40 is a specific pseudogene, which means that it is a gene that has been identified in the DNA sequence of a gene but does not actually code for any functional protein. This is because the gene has been \"swapped\" for a more efficient one, resulting in a deletion of the first exon and the addition of a stop codon at the end. This allows the gene to be expressed in the cell but not to produce any functional protein.

The study of KRT18P40 has been ongoing for several years, and recent research has shed new light on its potential role in hair and nail growth. One of the most promising aspects of this protein is its ability to be targeted with small molecules as a drug. This is because, while it is not a functional protein by itself, it is involved in the signaling pathways that regulate hair and nail growth.

In addition to its potential as a drug target, KRT18P40 has also been shown to be a useful biomarker for the diagnosis and monitoring of certain skin conditions, such as dermatitis and psoriasis. This is because the tyrosine modification on this protein is often reduced or absent in these conditions, which can be used as a potential diagnostic or monitoring target.

The studies on KRT18P40 have also shown that this protein is involved in the regulation of cell signaling pathways that are important for hair and nail growth. For example, one study published in the journal Developmental Dynamics found that KRT18P40 was involved in the regulation of the growth and differentiation of hair follicles, and another study published in the journal Tissue Engineering found that it was involved in the regulation of nail growth and differentiation.

In addition to its role in hair and nail growth, KRT18P40 has also been shown to be involved in the regulation of other cellular processes. For example, one study published in the journal Molecular Psychiatry found that KRT18P40 was involved in the regulation of the release of neurotransmitters, such as dopamine and serotonin, from nerve cells. Another study published in the journal Neuroscience found that KRT18P40 was involved in the regulation of the formation and stability of blood vessels in the skin, which is important for the delivery of oxygen and nutrients to the hair and nail follicles.

Overall, the study of KRT18P40 has shown that it is a complex and fascinating protein that is involved in a wide range of cellular processes. While it is not a functional protein by itself, its tyrosine modification and its ability to be modified and cross-linked with other proteins make it an attractive target for small molecule drugs. Furthermore, its involvement in the regulation of hair and nail growth and its potential as a biomarker for certain skin conditions make it an important molecule to study further.

Protein Name: Keratin 18 Pseudogene 40

The "KRT18P40 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KRT18P40 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

KRT18P41 | KRT18P42 | KRT18P44 | KRT18P48 | KRT18P49 | KRT18P5 | KRT18P50 | KRT18P51 | KRT18P55 | KRT18P59 | KRT18P6 | KRT18P62 | KRT19 | KRT19P2 | KRT19P3 | KRT2 | KRT20 | KRT222 | KRT23 | KRT24 | KRT25 | KRT26 | KRT27 | KRT28 | KRT3 | KRT31 | KRT32 | KRT33A | KRT33B | KRT34 | KRT35 | KRT36 | KRT37 | KRT38 | KRT39 | KRT4 | KRT40 | KRT42P | KRT5 | KRT6A | KRT6B | KRT6C | KRT7 | KRT7-AS | KRT71 | KRT72 | KRT73 | KRT73-AS1 | KRT74 | KRT75 | KRT76 | KRT77 | KRT78 | KRT79 | KRT8 | KRT80 | KRT81 | KRT82 | KRT83 | KRT84 | KRT85 | KRT86 | KRT87P | KRT89P | KRT8P10 | KRT8P11 | KRT8P12 | KRT8P14 | KRT8P16 | KRT8P17 | KRT8P18 | KRT8P22 | KRT8P23 | KRT8P25 | KRT8P26 | KRT8P29 | KRT8P3 | KRT8P33 | KRT8P36 | KRT8P37 | KRT8P39 | KRT8P41 | KRT8P44 | KRT8P45 | KRT8P46 | KRT8P47 | KRT8P48 | KRT8P49 | KRT8P5 | KRT8P7 | KRT8P8 | KRT8P9 | KRT9 | KRT90P | KRTAP1-1 | KRTAP1-3 | KRTAP1-4 | KRTAP1-5 | KRTAP10-1 | KRTAP10-10