CASR: A Potential Drug Target Or Biomarker (G846)

Target Name: CASR

NCBI ID: G846

CASR

CASR: A Potential Drug Target Or Biomarker

Calcium homeostasis is a critical regulatory process that plays a vital role in various physiological processes in the body. It is a delicate balance of intracellular and extracellular calcium levels that maintain proper cellular function and ensure homeostasis. One of the key regulators of calcium homeostasis is the Extracellular Calcium-Sensing Receptor (CASR), a G protein-coupled receptor that has been identified as a potential drug target or biomarker for various diseases.

CASR: Structure and Function

CASR is a transmembrane protein that is expressed in various tissues and cells in the body. It consists of an extracellular domain, a transmembrane region, and an intracellular domain. The extracellular domain is responsible for the binding of calcium ions, while the transmembrane region conducts s the signals from the extracellular domain to the intracellular domain. The intracellular domain contains a G protein-coupled receptor that is responsible for transmitting the signals to downstream signaling pathways.

CASR is a potent modulator of calcium homeostasis. It can regulate the activity of several intracellular signaling pathways, including the T-cell signaling pathway, the regulation of ion channels, and the regulation of protein kinase. It is also involved in the regulation of cellular processes such as cell adhesion, migration, and survival.

CASR has been implicated in various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. Its potential as a drug target or biomarker is due to its unique mechanism of action and its involvement in multiple cellular processes that are important for human health and disease.

Drug Targeting

CASR is a potential drug target due to its unique mechanism of action and its involvement in multiple cellular processes that are important for human health and disease. One of the main advantages of targeting CASR is its druggability. The extracellular domain of CASR contains a G protein -coupled receptor that is known to be responsive to small molecules such as inhibitors or modulators. This makes it possible to develop drugs that can interact with CASR and modulate its activity.

Another advantage of targeting CASR is its involvement in multiple cellular processes that are important for human health and disease. CASR is involved in the regulation of cellular processes such as cell adhesion, migration, and survival. It is also involved in the regulation of ion channels , which are critical for the proper functioning of cells. In addition, CASR is involved in the regulation of protein kinase, which is a critical regulator of cellular processes that are important for human health and disease.

Biomarker

CASR is also a potential biomarker for various diseases. Its involvement in the regulation of cellular processes makes it an attractive candidate for targeting diseases that are characterized by the disruption of cellular processes. For example, CASR is involved in the regulation of cell adhesion, which is disrupted in diseases such as cancer, neurodegenerative diseases, and cardiovascular diseases. Additionally, CASR is involved in the regulation of ion channels, which are disrupted in diseases such as hypertension and hypokalemia.

CASR has also been implicated in the regulation of protein kinase, which is disrupted in diseases such as cancer and neurodegenerative diseases. Its involvement in this process makes it an attractive candidate for targeting diseases that are characterized by the disruption of protein kinase activity.

Conclusion

In conclusion, CASR is a unique protein that has the potential to be a drug target or biomarker for various diseases. Its involvement in the regulation of cellular processes makes it an attractive candidate for targeting diseases that are characterized by the disruption of these processes. Further research is needed to fully understand the mechanism of action of CASR and its potential as a drug target or biomarker.

Protein Name: Calcium Sensing Receptor

Functions: G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547)

The "CASR Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CASR comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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