CASQ2: A Protein Targeted in Drug Development for Heart Failure, Neurodegenerative Disorders

Target Name: CASQ2

NCBI ID: G845

CASQ2

CASQ2: A Protein Targeted in Drug Development for Heart Failure, Neurodegenerative Disorders

CASQ2, or calsequestrin-2, is a protein that is expressed in various tissues throughout the body, including the brain, lungs, heart, and kidneys. It is a member of the cilia-associated protein (CAP) family, which is known for their role in the regulation of cell signaling and transport.

CASQ2 has been identified as a potential drug target due to its involvement in several cellular processes that are associated with various diseases, including heart failure, respiratory failure, and neurodegenerative disorders. It is also expressed in various tissues that are often affected by these diseases, such as the lungs, heart, and brain.

One of the key functions of CASQ2 is its role in the regulation of the actinin cytoskeleton, which is responsible for the movement of cells and the formation of tissues.CASQ2 has been shown to play a key role in the regulation of actinin cytoskeleton structure and function, which is essential for the proper functioning of many cellular processes.

CASQ2 is also involved in the regulation of the cytoskeleton in the context of neurodegenerative diseases. neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are characterized by the progressive loss of brain cells and the formation of aggregates of damaged proteins.CASQ2 has been shown to be involved in the regulation of the structure and function of the neurotransmitter dopamine, which is a key protein involved in the development and progression of neurodegenerative diseases.

CASQ2 is also involved in the regulation of the cytoskeleton in the context of respiratory failure.Respiratory failure is a condition in which the body is unable to deliver enough oxygen to the body's cells, leading to a range of symptoms, including fatigue, coughing, and shortness of breath.CASQ2 has been shown to be involved in the regulation of the structure and function of the cytoskeleton in the lungs, which plays a critical role in the regulation of oxygen transport to the body's cells.

CASQ2 is also a potential drug target in the context of heart failure. Heart failure is a condition in which the heart is unable to pump enough blood to the body's cells, leading to a range of symptoms, including palpitations, shortness of breath, and fatigue.CASQ2 has been shown to be involved in the regulation of the cytoskeleton in the heart, which plays a critical role in the regulation of blood pressure and the flow of blood to the body's cells.

In conclusion, CASQ2 is a protein that is involved in a wide range of cellular processes that are important for the proper functioning of many tissues. It is a potential drug target due to its involvement in several diseases, including heart failure, respiratory failure, and neurodegenerative disorders. Further research is needed to fully understand the role of CASQ2 in these diseases and to develop effective treatments.

Protein Name: Calsequestrin 2

Functions: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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