Understanding The Role of DDI1 in Cellular Processes (G414301)

Target Name: DDI1

NCBI ID: G414301

DDI1

Understanding The Role of DDI1 in Cellular Processes

DDI1 (DDI1, DNA-damage inducible 1, homolog 1) is a gene that encodes a non-coding RNA molecule that plays a critical role in cellular processes. The RNA molecule is composed of 21 amino acids and has a calculated molecular weight of 20 kDa. It is located on chromosome 16 and has been implicated in various cellular processes, including DNA replication, repair, and cell growth.

DDI1 is a protein that has been shown to play a role in the regulation of DNA damage repair. It has been shown to interact with several DNA repair proteins, including the protein NIP (Nucleotide-Initiating Repair) and the protein DNA-PDZ (DNA-Protein Interactionz).

One of the functions of DDI1 is to promote the formation of double-strand breaks in DNA. This can occur as a result of DNA damage caused by various factors, such as UV radiation, radiation, or chemicals. DDI1 has been shown to induce double-strand breaks in human cells and to have a positive effect on the repair of these types of damage.

Another function of DDI1 is to regulate the expression of genes. This is done by binding to specific DNA sequences and preventing the binding of RNA polymerase, which is responsible for transcribing DNA information into RNA. This can result in the activation or repression of gene expression.

DDI1 has also been shown to play a role in the regulation of cell cycle progression. It has been shown to promote the G1 phase of the cell cycle and to inhibit the S phase. This can result in the arrest of cell division at the G1 checkpoint, which is a critical step in the cell cycle.

DDI1 has also been shown to play a role in the regulation of inflammation. It has been shown to promote the production of pro-inflammatory cytokines and to inhibit the production of anti-inflammatory cytokines. This can result in the activation of immune cells and the production of pro-inflammatory molecules.

DDI1 is also a potential drug target. The development of new treatments for cancer and other diseases often involves the inhibition of the activity of DDI1 and other genes that play a role in cellular processes.

Conclusion

DDI1 is a non-coding RNA molecule that has been shown to play a critical role in various cellular processes. It is involved in the regulation of DNA damage repair, cell cycle progression, and inflammation. The development of new treatments for cancer and other diseases often involves the inhibition of the activity of DDI1 and other genes that play a role in cellular processes. Further research is needed to fully understand the role of DDI1 and its potential as a drug target.

Protein Name: DNA Damage Inducible 1 Homolog 1

Functions: Probable aspartic protease (Probable). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612)

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