MTHFR: A Protein Involved in Blood Cell Production and Immune Function

Target Name: MTHFR

NCBI ID: G4524

MTHFR

MTHFR: A Protein Involved in Blood Cell Production and Immune Function

MTHFR (MutL homolog 1) is a gene that encodes a protein known as MTHFR. MTHFR is a protein that is expressed in most tissues of the body and plays a critical role in the regulation of the body's ability to produce blood cells.

MTHFR is a protein that is synthesized from a single amino acid at position 648 in the DNA sequence. It consists of 1,947 amino acids and has a calculated molecular mass of 21.9 kDa. MTHFR is predominantly expressed in the liver, where it is involved in the synthesis and degradation of erythropoietin (EPO), a hormone that stimulates the production of red blood cells in the bone marrow.

MTHFR is also involved in the regulation of the production of white blood cells, including granulocytes and monocytes. It has been shown to play a role in the development and maintenance of normal immune function, as well as in the regulation of inflammation.

MTHFR is a protein that is often targeted by drugs because of its involvement in the regulation of blood cell production and immune function. One drug that is currently in use to treat these conditions is a drug called \"Urokinase\". This drug is used to treat anemia in patients with chronic kidney disease, and it works by increasing the number of red blood cells in the body.

Another drug that is being developed to target MTHFR is a drug called \"AMG 701\". This drug is being developed to treat anemia in patients with acute myeloid leukemia (AML), and it works by inhibiting the activity of a protein called FasL, which is involved in the regulation of blood cell production.

MTHFR is also being targeted by researchers as a potential biomarker for the diagnosis and prognosis of various diseases, including cancer. Researchers have shown that MTHFR levels are often elevated in patients with certain types of cancer, and that these levels can be used as a biomarker to predict the effectiveness of certain treatments.

In addition to its potential as a drug target, MTHFR is also an interesting protein for research into the regulation of blood cell production and immune function. Researchers are still working to fully understand the mechanisms by which MTHFR is involved in these processes, and they are continuing to explore its potential as a tool for the study of these important biological processes.

Overall, MTHFR is a protein that is involved in the regulation of blood cell production and immune function. It is a potential drug target and a biomarker for the diagnosis and prognosis of various diseases. Further research is needed to fully understand its role in these processes and to explore its potential as a tool for the study of these important biological processes.

Protein Name: Methylenetetrahydrofolate Reductase

Functions: Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine (PubMed:29891918). Represents a key regulatory connection between the folate and methionine cycles (Probable)

The "MTHFR Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MTHFR comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets