Unlocking the Potential of CALHM2: A Potential Drug Target and Biomarker

Target Name: CALHM2

NCBI ID: G51063

CALHM2

Unlocking the Potential of CALHM2: A Potential Drug Target and Biomarker

Introduction

CALHM2, a member of the Calbindin gene family, has been identified as a potential drug target and biomarker for various diseases, including cancer. Its unique sequence similarity to other Calbindin genes, member A (CALHM1), has piqued researchers' interest in exploring its biological functions and the potential it holds for therapeutic applications. In this article, we will delve into the biology of CALHM2, its potential drug target status, and its potential as a biomarker for various diseases.

Sequence Similarity and biological function

The Calbindin gene family is a group of genes that encode a calcium-dependent protein that is involved in a variety of cellular processes, including cell signaling, cytoskeletal organization, and neurotransmission. The genes in the Calbindin family are characterized by a characteristic sequence similarity, known as the calbindin domain, which is a unique combination of amino acids that gives the proteins their unique structure and function.

CALHM2, as a member of the Calbindin gene family, is characterized by a similar calbindin domain to its ancestor, member A. However, its sequence is distinct enough to warrant further investigation. The sequence similarity between CALHM2 and member A is 96% amino acid identity and 4% sequence identity, which indicates that they share a significant degree of biological function.

Potential Drug Target

The identification of a potential drug target is based on the presence of a unique protein that can be targeted by small molecules, called ligands. In the case of CALHM2, its sequence similarity to member A and its unique function in calcium signaling make it an attractive target for drug development.

CALHM2 functions as a calcium-dependent protein that plays a role in the regulation of cellular processes, including cell signaling, cytoskeletal organization, and neurotransmission. It is involved in the regulation of several cellular processes, including:

1. Cell signaling: Calbindin proteins are involved in intracellular signaling, which is critical for the regulation of cellular processes. They interact with various signaling molecules, including neurotransmitters, to regulate cellular signaling pathways.

2. Cytoskeletal organization:Calbindin proteins are involved in the regulation of cytoskeletal organization, which is critical for the proper functioning of cells. They interact with actin filaments and microtubules to regulate their structure and function.

3. Neurotransmission: Calbindin proteins are involved in the regulation of neurotransmission, which is the transfer of signals from the brain to the rest of the body. They interact with neurotransmitters to regulate the release and uptake of these molecules.

4. Cell adhesion:Calbindin proteins are involved in the regulation of cell adhesion, which is the process by which cells stick together to form tissues and organs. They interact with adhesion molecules, such as cadherins and immunoglobulin-like cell adhesion molecules (Ig- CAMs), to regulate the stickiness of cells to each other.

Given its involvement in these cellular processes, the potential of CALHM2 as a drug target is significant. By targeting the regulation of these processes, drugs can be developed to treat a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Biomarker Potential

The potential of CALHM2 as a biomarker for various diseases is based on its unique expression patterns in different tissues and its involvement in the regulation of cellular processes that are associated with disease.

1. Cancer:Calbindin proteins have been shown to be involved in the regulation of cell signaling, which is critical for the development and progression of cancer. By targeting the regulation of

Protein Name: Calcium Homeostasis Modulator Family Member 2

Functions: Pore-forming subunit of a voltage-gated ion channel

The "CALHM2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CALHM2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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