PHF20L1: A Protein Involved in Cell Signaling, DNA Replication and Metabolism

Target Name: PHF20L1

NCBI ID: G51105

PHF20L1

PHF20L1: A Protein Involved in Cell Signaling, DNA Replication and Metabolism

PHF20L1, also known as PHD finger protein 20 like 1, is a protein that is expressed in various tissues throughout the body. It is a member of the PHD finger gene family, which is known for the presence of a conserved domain that is similar to the protein PHD finger 1. PHF20L1 is a 20-kDa protein that is expressed in the liver, lung, and heart. It is involved in various cellular processes, including cell signaling, DNA replication, and metabolism.

One of the key functions of PHF20L1 is its role in cell signaling. It is a signaling molecule that can interact with various signaling pathways, including the PI3K/Akt signaling pathway. This pathway is involved in various cellular processes, including cell survival, angiogenesis, and inflammation. By participating in this pathway, PHF20L1 can contribute to the regulation of cellular processes that are important for human health and disease.

Another function of PHF20L1 is its role in DNA replication. It is a protein that is involved in the regulation of DNA replication, which is an essential process for the development and maintenance of cellular genomes. PHF20L1 has been shown to play a role in the regulation of DNA replication in various cellular contexts, including the regulation of the timing of DNA replication during cell division.

In addition to its role in cell signaling and DNA replication, PHF20L1 is also involved in metabolism. It is a protein that is involved in the regulation of various metabolic processes, including the regulation of lipid metabolism and the detoxification of harmful substances. This protein has been shown to play a role in the regulation of lipid metabolism, including the regulation of the levels of low-density lipoprotein (LDL) cholesterol in the blood.

PHF20L1 is also a potential drug target. Its involvement in various cellular processes, including cell signaling, DNA replication, and metabolism, makes it a potential target for small molecules that can modulate these processes. For example, drugs that can inhibit the activity of PHF20L1 have been shown to have potential therapeutic benefits in various diseases, including cancer, neurodegenerative diseases, and cardiovascular disease.

In conclusion, PHF20L1 is a protein that is involved in various cellular processes that are important for human health and disease. Its role in cell signaling, DNA replication, and metabolism makes it a potential target for small molecules that can modulate these processes. Further research is needed to fully understand the functions of PHF20L1 and its potential as a drug target.

Protein Name: PHD Finger Protein 20 Like 1

Functions: Is a negative regulator of proteosomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (PubMed:24492612, PubMed:29358331). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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