HERC5: A Protein Regulator of Cellular Processes (G51191)

Target Name: HERC5

NCBI ID: G51191

HERC5

HERC5: A Protein Regulator of Cellular Processes

HERC5, also known as HSP70, is a protein that is expressed in various tissues throughout the body. It is a heat shock protein (HSP) that is involved in the regulation of protein synthesis and degradation. HSPs are proteins that can be derived from a variety of organisms, including bacteria, yeast, and eukaryotes. They are characterized by the presence of a nucleotide-binding oligomerization domain (NBD), which is a region of the protein that contains a nucleotide-binding site, as well as a conserved amino acid sequence that is involved in protein-protein interactions.

HERC5 is a 70-kDa protein that is expressed in a variety of tissues, including muscle, heart, liver, and brain. It is highly conserved across different species, and its sequence is highly conserved among species. HERC5 is localized to the cytoplasm and is associated with various cellular processes, including cell signaling, DNA replication, and stress response.

One of the unique features of HERC5 is its ability to interact with other proteins. It has been shown to interact with a variety of protein partners, including caseins, nucleotide-binding oligomerization domains (NBDs), and histone-like proteins. HERC5 has been shown to play a role in the regulation of protein synthesis and degradation, as well as in the regulation of cellular processes such as cell signaling and stress response.

In addition to its role in protein regulation, HERC5 has also been shown to be involved in the regulation of cellular processes. It has been shown to be involved in the regulation of cell cycle progression, cell signaling, and DNA replication. HERC5 has also been shown to play a role in the regulation of cell death, as it has been shown to be involved in the regulation of apoptosis.

Given its role in the regulation of cellular processes, HERC5 is a potential drug target. Researchers have been interested in identifying small molecules that can interact with HERC5 and modulate its activity. One of the most promising strategies for the study of HERC5 is the use of high-throughput screening (HTS) techniques to identify small molecules that can interact with HERC5. HTS techniques involve the use of large libraries of compounds to identify those that interact with a specific target protein.

In addition to the use of HTS, there are also a variety of other approaches that can be used to study HERC5. One approach is to use RNA interference (RNAi) technology to knockdown the expression of HERC5 and to study its function. RNAi is a technique that involves the use of small interfering RNA (siRNA) to knockdown the expression of a specific gene. This technique can be used to identify potential drug targets and to study the function of HERC5.

Another approach that can be used to study HERC5 is the use of immunoprecipitation (IP) technology. IP is a technique that involves the use of antibodies to capture specific proteins from a cell or a sample, and then to purify and analyze the captured proteins. This technique can be used to study the distribution and function of HERC5 in cells.

Despite the many advances in the study of HERC5, much work remains to be done. There are still many questions about its function in cellular processes, and many potential drug targets. Further research is needed to fully understand the role of HERC5 in cellular processes and to identify effective drug targets.

In conclusion, HERC5 is a protein that is expressed in various tissues throughout the body and is involved in the regulation of protein synthesis and degradation. It has been shown to interact with a variety of protein partners and to play a role in the regulation of cellular processes such as cell signaling and stress response. Given its potential role in cellular processes, HERC5 is a promising drug target for the study of protein regulation and cellular processes. Further research is needed to fully understand its function and to identify effective drug targets.

Protein Name: HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 5

Functions: Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15

The "HERC5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HERC5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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