HERC4: A Protein Regulating Cellular Processes (G26091)

Target Name: HERC4

NCBI ID: G26091

HERC4

HERC4: A Protein Regulating Cellular Processes

HERC4 (HECT-type E3 ubiquitin transferase HERC4) is a protein that plays a crucial role in the regulation of cellular processes in the body. It is a key player in the ubiquitin system, which is responsible for the degradation of damaged or unnecessary proteins. HERC4 is a 21-kDa protein that consists of 218 amino acid residues. It is expressed in most tissues of the body and is involved in the regulation of various cellular processes.

One of the key functions of HERC4 is its role in the ubiquitin system. Ubiquitin is a protein that is covalently attached to the ends of linear proteins to facilitate their degradation. HERC4 is one of the enzymes that transfers the ubiquitin tag to the protein target. This transferase activity is critical for the regulation of protein homeostasis, as it helps to ensure that proteins are either retained or degraded according to their functional status.

HERC4 is also involved in the regulation of cellular signaling pathways. Many cellular signaling pathways involve the ubiquitinylation of protein targets, which is the covalent attachment of the ubiquitin tag to the target protein. HERC4 is involved in the regulation of several signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway.

HERC4 is also involved in the regulation of cell adhesion. Many tissues of the body are composed of cells that are in close contact with each other, and cell-cell adhesion is critical for the maintenance of tissue structure and function. HERC4 is involved in the regulation of cell-cell adhesion by ubiquitinylation of adhesion molecules such as cadherins and immunoglobulin E (IgE).

In addition to its role in the ubiquitin system, HERC4 is also involved in the regulation of DNA replication and repair. DNA replication and repair are critical for the maintenance of genetic accuracy, and HERC4 is involved in the regulation of these processes by ubiquitinylation of DNA replication factors such as histone modifications and transcription factors.

HERC4 is also involved in the regulation of cellular metabolism. It is involved in the regulation of protein synthesis and degradation, as well as in the regulation of carbohydrate metabolism.

In conclusion, HERC4 is a protein that plays a crucial role in the regulation of cellular processes in the body. Its function in the ubiquitin system, the regulation of signaling pathways, cell adhesion, DNA replication and repair, and cellular metabolism make it an attractive drug target or biomarker. Further research is needed to fully understand the role of HERC4 in the regulation of cellular processes and to develop effective therapies based on this protein.

Protein Name: HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 4

Functions: Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates

The "HERC4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HERC4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets