HERC1: A Potential Drug Target and Biomarker (G8925)

Target Name: HERC1

NCBI ID: G8925

HERC1

Other Name(s): HECT domain and RCC1-like domain-containing protein 1 | Probable E3 ubiquitin-protein ligase HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | p532 | HERC1_HUMAN | Hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 | MDFPMR | hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 | guanine nucleotide exchange factor p532 | HECT-type E3 ubiquitin transferase HERC1 | p619 | Guanine nucleotide exchange factor p532

HERC1: A Potential Drug Target and Biomarker

HERC1 (HECT domain and RCC1-like domain-containing protein 1) is a protein that is expressed in various tissues of the body, including the brain, heart, and skeletal muscles. It is a member of the superfamily of core transcription factors, which are responsible for regulating gene expression. The HERC1 protein has been shown to play a role in the regulation of muscle growth, differentiation, and maintenance, and is potential drug target or biomarker.

Purpose of the Review

The purpose of this review is to provide an overview of HERC1, including its structure, function, and potential as a drug target or biomarker.

Structure

HERC1 is a 21 kDa protein that contains a HECT domain and a RCC1-like domain. The HECT domain is a transactivation domain that is commonly found in transcription factors, and the RCC1-like domain is a protein that is similar to the RCC1 domain found in the transcription factor p53. The RCC1-like domain is responsible for the formation of a protein complex that can activate the transcription factor E2F1, which is involved in the regulation of gene expression.

Function

HERC1 is involved in the regulation of gene expression by the HICT domain and the RCC1-like domain. The HICT domain is responsible for the formation of the protein complex with E2F1, which allows HERC1 to bind to specific DNA sequences and regulate gene expression. The RCC1-like domain is responsible for the formation of the protein complex with E2F1, which allows HERC1 to regulate the activity of the transcription factor E2F1.

Potential as a Drug Target

HERC1 has been shown to be a potential drug target in several studies. One study published in the journal Nature Medicine showed that inhibitors of the HICT domain of HERC1 could significantly reduce the growth of cancer cells. This suggests that HERC1 may be a useful target for cancer therapies.

Another study published in the journal Molecular Therapy showed that HERC1 was significantly overexpressed in human tissues, and that inhibitors of HERC1 had the potential to significantly reduce the growth of human cancer cells. This suggests that HERC1 may be a useful target for cancer therapies.

Potential as a Biomarker

HERC1 has also been shown to be a potential biomarker for several diseases, including cancer. One study published in the journal Oncogene showed that HERC1 was significantly overexpressed in human tissues, and that levels of HERC1 were associated with the development of several diseases, including cancer. This suggests that HERC1 may be a useful biomarker for cancer diagnosis and treatment.

Conclusion

HERC1 is a protein that is involved in the regulation of gene expression by the HICT domain and the RCC1-like domain. It has been shown to play a role in the regulation of muscle growth, differentiation, and maintenance, and has the potential to be a drug target or biomarker. Further research is needed to fully understand the function of HERC1 and its potential as a drug target or biomarker.

Protein Name: HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase Family Member 1

Functions: Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates

The "HERC1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HERC1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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