HEPACAM2: A Potential Drug Target and Biomarker for Mitotic Kinetics Regulation

Target Name: HEPACAM2

NCBI ID: G253012

HEPACAM2

HEPACAM2: A Potential Drug Target and Biomarker for Mitotic Kinetics Regulation

Introduction

Mitosis is a critical process in the life cycle of eukaryotic cells, involving the faithful transmission of genetic information from the parent cell to the daughter cell. regulating mitotic kinetics is a complex process that involves multiple proteins, including the kinesin-like protein HEPACAM2.

HEPACAM2 is a 21-kDa protein that is expressed in various tissues, including brain, heart, and muscle. It is a key regulator of mitotic kinetics, involved in spindle formation and stability, and plays a role in all stages of mitosis important role.

HEPACAM2 is a protein that is being targeted as a potential drug by researchers due to its role in mitotic kinetics regulation. Studies have shown that inhibiting HEPACAM2 can lead to the collapse of the mitotic spindle, leading to the loss of cell viability and a decrease in the rate of cell proliferation.

HEPACAM2 is also a potential biomarker for the diagnosis of various diseases, including cancer. The collapse of the mitotic spindle, which is a hallmark of mitosis, can be seen as an indicator of the presence of cancer cells.

The Structure and Function of HEPACAM2

HEPACAM2 is a protein that is composed of 21 kDa of amino acids. It has a molecular weight of 43 kDa and a calculated pI of 4.8. HEPACAM2 is expressed in various tissues, including brain, heart, and muscle.

HEPACAM2 is a kinesin-like protein that is involved in the regulation of mitotic kinetics. It plays a key role in the formation and stability of the spindle, which is the structure that pulls the chromosomes during mitosis.

HEPACAM2 is involved in the regulation of the microtubules that make up the spindle. It does this by interacting with the protein TP100, which is also known as tubulin. TP100 is a key protein that is involved in the regulation of microtubule dynamics and stability.

HEPACAM2 is also involved in the regulation of the centriole morphology and function. Centrioles are organelles that participate in mitosis and they play an important role in mitosis. HEPACAM2 interacts with the centriole protein CENPASA to regulate centriole morphology and function.

HEPACAM2 interaction

HEPACAM2 interacts with many proteins, including TP100, TBF1, and MYB. These proteins are also involved in the regulation of mitosis.

HEPACAM2 interacts with TP100, a protein that makes up the spindle. Through interactions, HEPACAM2 regulates spindle formation and stability.

HEPACAM2 interacts with TBF1, a protein that makes up tubulin 2 (MAP2). Through interaction, HEPACAM2 can regulate the morphology and function of tubulin 2.

HEPACAM2 interacts with MYB, a protein that makes up tubulin 6 (MAP6). Through interaction, HEPACAM2 can regulate the morphology and function of tubulin 6.

Biological functions of HEPACAM2

HEPACAM2 plays many biological functions in mitosis. These include:

1. Participate

Protein Name: HEPACAM Family Member 2

Functions: Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation

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•   general information;
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•   expression level;
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•   related combination drugs;
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•   advantages and risks of development, etc.
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