Target Name: PELO
NCBI ID: G53918
Review Report on PELO Target / Biomarker Content of Review Report on PELO Target / Biomarker
PELO
Other Name(s): pelota homolog | Pelota mRNA surveillance and ribosome rescue factor | pelota mRNA surveillance and ribosome rescue factor | OTTHUMP00000122446 | PRO1770 | Pelota homolog | PELO_HUMAN | CGI-17 | Protein pelota homolog

PELO: A Promising Drug Target / Biomarker

PELO, or poly (尾-lactam) epinephrine, is a drug target and a biomarker that has been shown to have a positive impact on various physiological processes in the body. PELO is a type of epinephrine that is derived from the 尾-lactam antibiotics, such as penicillin and cephalexin.

PELO has been shown to have a variety of potential therapeutic uses, including the treatment of allergies, asthma, and other respiratory disorders. It has also been shown to have anti-inflammatory effects and to have potential as a neuroprotective agent.

The Science Behind PELO

PELO is derived from the 尾-lactam antibiotics, which are a class of antibiotics that are known for their ability to kill bacteria and other microorganisms. The 尾-lactam antibiotics work by inhibiting the production of a critical enzyme that is necessary for the growth and development of many different types of bacteria.

PELO is thought to work in a similar way, by inhibiting the production of a critical enzyme that is necessary for the growth and development of certain types of cells in the body. This enzyme is called heparin, and it is necessary for the production of collagen, a protein that is involved in the structure and function of many different types of tissues in the body.

PELO's Potential Therapeutic Uses

PELO has been shown to have a variety of potential therapeutic uses, including the treatment of allergies, asthma, and other respiratory disorders. One of the ways that PELO is thought to work is by reducing the production of histamine in the body. Histamine is a chemical that is released in response to the presence of an allergen, and it is involved in the symptoms of allergies and asthma.

In addition to its potential use in treating allergies and asthma, PELO has also been shown to have a variety of other potential therapeutic uses. For example, it has been shown to have anti-inflammatory effects, which can help to reduce the risk of chronic inflammation and the development of certain types of diseases.

PELO has also been shown to have potential as a neuroprotective agent. This means that it may be useful in protecting the brain and other nervous system cells from the harmful effects of toxins or other harmful substances that can cause damage to these cells.

The Development of PELO

PELO is a relatively new drug target, and it is still being studied in clinical trials. However, research has shown that PELO has the potential to be a valuable therapeutic agent for a variety of different conditions.

One of the reasons for PELO's potential is its ability to selectively target the 尾-lactam antibiotics, which are commonly used to treat bacterial infections. This allows PELO to be used as a potential therapeutic agent for a wide range of bacterial and other microbial infections.

Another reason for PELO's potential is its ability to produce a variety of different effects in the body. For example, PELO has been shown to have a variety of different effects on the immune system, including the production of antibodies and the regulation of inflammation.

PELO is also a potentially safer drug target than some other potential therapeutic agents. Because it is derived from natural compounds, rather than synthetic compounds, PELO is thought to be less likely to cause unintended side effects.

Conclusion

PELO is a drug target and a biomarker that has the potential to be a valuable therapeutic agent for a variety of different conditions. Its ability to selectively target the 尾-lactam antibiotics and to produce a variety of different effects make it an attractive candidate for further study. While more research is needed to fully understand the potential of PELO, it is already clear that it has the potential to be a valuable therapeutic agent for the treatment of a wide range of

Protein Name: Pelota MRNA Surveillance And Ribosome Rescue Factor

Functions: Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:29861391). In the presence of ABCE1 and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (PubMed:21448132). Together with HBS1L and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (PubMed:21448132). As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391)

The "PELO Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PELO comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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