PGK1: A Potential Drug Target and Biomarker for Various Diseases

Target Name: PGK1

NCBI ID: G5230

PGK1

PGK1: A Potential Drug Target and Biomarker for Various Diseases

PGK1 (Post-Translational Modification gene 1) is a gene that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. PGK1 is a gene that has been shown to play a role in the regulation of cellular processes that are important for the development and progression of these diseases.

The PGK1 gene is located on chromosome 18 and encodes a protein that is involved in the regulation of a variety of cellular processes, including cell adhesion, migration, and the formation of tight junctions. PGK1 has also been shown to play a role in the regulation of the immune response, as well as in the regulation of cell death and survival.

One of the most promising aspects of PGK1 is its potential as a drug target. By inhibiting the activity of PGK1, researchers have been able to reduce the growth and spread of cancer cells, as well as improve the survival of neurodegenerative disease patients. Additionally, PGK1 has been shown to be involved in the regulation of autoimmune disorders, which are characterized by the production of antibodies that target the body's own cells. By inhibiting the activity of PGK1, researchers have been able to reduce the severity and frequency of autoimmune disease.

Another promising aspect of PGK1 is its potential as a biomarker. By analyzing the levels of PGK1 in cancer cells, researchers have been able to monitor the effectiveness of anti-cancer drugs and to identify new potential drug targets. Additionally, PGK1 has been shown to be involved in the regulation of cellular processes that are important for the development and progression of neurodegenerative diseases, which makes it an attractive candidate for use as a biomarker for these conditions.

In conclusion, PGK1 is a gene that has the potential to be a drug target and biomarker for a variety of diseases. By inhibiting the activity of PGK1, researchers have been able to reduce the growth and spread of cancer cells, improve the survival of neurodegenerative disease patients, and reduce the severity and frequency of autoimmune disease. Further research is needed to fully understand the role of PGK1 in these diseases and to identify new potential drug targets.

Protein Name: Phosphoglycerate Kinase 1

Functions: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959)

The "PGK1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PGK1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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