Peroxisomal Biogenesis Factor 12 (PEX12): A Potential Drug Target and Biomarker

Target Name: PEX12

NCBI ID: G5193

PEX12

Peroxisomal Biogenesis Factor 12 (PEX12): A Potential Drug Target and Biomarker

Peroxisomal biogenesis factor 12 (PEX12) is a protein that plays a crucial role in the biogenesis of peroxisomes, which are organelles responsible for the production of unusual lipids, including those with potential therapeutic applications. PEX12 is a member of the PEX gene family, which is known for producing a wide range of proteins involved in various cellular processes. Importantly, defects in PEX12 have been implicated in a range of diseases, including obesity, diabetes, and neurodegenerative disorders. As such, targeting PEX12 has the potential to lead to new therapeutic approaches for a variety of conditions.

PEX12 Functions and Importance

PEX12 is a 21-kDa protein that is expressed in various tissues and cells, including adipocytes, liver, and pancreatic beta cells. It is a key regulator of peroxisome biogenesis, as well as the maturation and transport of peroxisomes. PEX12 functions by forming a complex with the peroxisome-associated protein (PAP) and by participating in the regulation of peroxisome-associated molecular chaperones (PAMCs).

In addition to its role in peroxisome biogenesis, PEX12 has also been shown to play a critical role in the regulation of various cellular processes, including metabolism, inflammation, and autophagy. For example, PEX12 has been shown to be involved in the regulation of lipid metabolism, as it has been shown to interact with various lipid-related genes, including lipase and PPAR伪.

PEX12 Deficiency and Disease

PEX12 is often missing or has reduced levels in tissues or cells that are affected by various diseases, including obesity, diabetes, and neurodegenerative disorders. For example, individuals with the genetic disorder, progressive familial intrahepatic cholestasis (PFIC), have defective PEX12 and are characterized by the accumulation of toxic lipids in the liver. PEX12 levels are also often reduced in individuals with non-alcoholic steatohepatitis (NASH), a common form of obesity.

In addition to its role in disease, PEX12 may also be a potential drug target. The use of PEX12 as a drug target has the potential to treat a variety of conditions, including obesity, diabetes, and neurodegenerative disorders. For example, inhibitors of PEX12 have been shown to be effective in reducing the accumulation of toxic lipids in the liver in individuals with PFIC. Additionally, PEX12 has been shown to be involved in the regulation of various cellular processes, making it a potential target for drugs that aim to modulate cellular signaling pathways.

Methods

To better understand the role of PEX12 in various cellular processes, researchers have used a variety of techniques to study its function. One approach has been to use RNA interference (RNAi) to knockdown PEX12 levels in cells and to assess the impact on cellular processes. RNAi experiments have shown that PEX12 plays a critical role in the regulation of various cellular processes, including metabolism, inflammation, and autophagy.

Another approach has been to use mass spectrometry (MS) to identify and quantify PEX12 in tissues and cells. MS has been used to determine the levels of PEX12 in various tissues and cells and to study its localization and stability.

Conclusion

PEX12 is a protein that is involved in the regulation of various cellular processes and has been implicated in a range of diseases, including obesity, diabetes, and neurodegenerative disorders. In addition to its role in peroxisome biogenesis, PEX12 has also been shown to play a critical role in the regulation of various cellular processes and may be a potential drug target. Further research is needed to fully understand the role of PEX12 in

Protein Name: Peroxisomal Biogenesis Factor 12

Functions: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:9354782, PubMed:9632816, PubMed:24662292). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (PubMed:24662292). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)

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