A Fish out of Water: The Potential Drug Target Profilin-1 (ISO Form 2)

Target Name: PFN1

NCBI ID: G5216

PFN1

A Fish out of Water: The Potential Drug Target Profilin-1 (ISO Form 2)

Profilin-1 (ISO Form 2) is a protein that plays a critical role in the regulation of water transport and cell signaling in various organisms, including fish and humans. It is a member of the PFN (protein family N) and is localized to the endoplasmic reticulum (ER) and/or endosomal system (ES). PFNs are involved in the delivery and retrieval of a wide variety of proteins, including drug targets, throughout the body. As such, Profilin-1 is of interest as a potential drug target or biomarker.

The PFN Family: A Journey Through the Protein Data Bank

The protein family N, also known as the PFN (protein family N), is a large family of transmembrane proteins that play a crucial role in various cellular processes, including cytoskeletal organization, cell signaling, and drug delivery. PFNs are characterized by the presence of a N-terminal transmembrane domain, a catalytic center, and a carboxylic acid residue at their C-terminus.

Overview of PFN1 (ISO Form 2)

PFN1 is a member of the PFN family and is expressed in a variety of tissues, including the brain, heart, kidneys, and intestine. It is primarily localized to the ER and ES and is involved in the delivery and retrieval of proteins, including drug targets, throughout the body.

PFN1 functions as a scaffold protein, helping to regulate the trafficking of proteins to their final destinations. It does this by interacting with the cytoskeleton and the endoplasmic reticulum (ER) through its N-terminal transmembrane domain. This domain is involved in the formation of a complex with the microtubules of the ER and the transmembrane region of the ES. This complex serves as a platform for the recruitment of various partner proteins to the ER and ES, thereby allowing PFN1 to regulate the trafficking of these proteins to their final destinations.

PFN1 is also involved in the regulation of cell signaling, including the production and degradation of signaling molecules, such as growth factors and cytokines. This is accomplished through its catalytic center, which is thought to participate in the regulation of protein-protein interactions and the metabolism of signaling molecules.

In addition to its role in cell signaling, PFN1 is also implicated in the regulation of water transport. This is achieved through its ability to interact with various proteins involved in the production and degradation of water-soluble vesicles, such as aquaporins. By doing so, PFN1 helps to regulate the movement of water and solutes into and out of cells, ensuring the proper functioning of various physiological processes.

PFN1 as a Drug Target: Potential Therapies

The potential use of PFN1 as a drug target is due to its involvement in various cellular processes that are often disrupted in diseases, such as cancer, neurodegenerative diseases, and cardiovascular diseases. As such, several studies have investigated the effects of drugs that target PFN1 and have shown promise in clinical trials.

One of the most promising strategies for targeting PFN1 is the use of small molecules that can modulate its activity. For example, several studies have shown that inhibitors of the PFN1 catalytic center can reduce the production of vesicles in cells, leading to a decrease in the amount of water transport and an increase in the sensitivity to drought stress. These inhibitors have been shown to be effective in a variety of cellular models, including cancer, neurodegenerative diseases, and cardiovascular diseases.

Another approach to targeting PF

Protein Name: Profilin 1

Functions: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR

The "PFN1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PFN1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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