PEX5: A Potential Drug Target for Various Diseases (G5830)

Target Name: PEX5

NCBI ID: G5830

PEX5

PEX5: A Potential Drug Target for Various Diseases

PEX5 (Perfluxin-Ex identifier) 鈥嬧?媔s a protein that is expressed in various tissues throughout the body. It is a potent hydrophobic transcription factor that is found to be involved in regulating a variety of physiological processes, such as cell proliferation, differentiation, and tumor development. Variations in PEX5 are associated with the development of many diseases, including cancer and neurodegenerative diseases. Therefore, PEX5 has become a research subject that has attracted much attention and may be a potential drug target or biomarker.

Structure and function

PEX5 is a polypeptide with a length of 214 amino acids, consisting of two domains: N-terminal domain and C-terminal domain. The N-terminal domain contains a hydrophobic 伪-helix, and the C-terminal domain contains a hydrophilic 尾-coil containing cysteine. This complex structure makes PEX5 extremely stable and can form stable interactions, further enhancing its function.

PEX5 functions to regulate a variety of cellular processes in a variety of ways. In cell proliferation, PEX5 can promote cell cycle progression and spindle formation, and also plays a role in apoptosis. During cell differentiation and tumor development, PEX5 can regulate cell morphology, proliferation and survival, and play a role in tumor growth and metastasis.

PEX5 also interacts with many important biological processes. In cell signaling, PEX5 can bind to a variety of signaling molecules, including Wnt, Notch and Hedgehog. In cell adhesion and migration, PEX5 can interact with molecules such as integrins to promote cell migration and invasion.

PEX5 mutations and disease

Variations in PEX5 are associated with the occurrence of various diseases. Studies have found that variations in the PEX5 gene are related to the occurrence of many cancers (including lung cancer, liver cancer, breast cancer, and ovarian cancer, etc.). For example, mutations in the PEX5 gene are associated with the progression and increased invasiveness of lung cancer. In addition, variations in the PEX5 gene are also associated with the occurrence of diseases such as liver cirrhosis and diabetes.

Detection of PEX5

At present, the detection of PEX5 mainly includes methods such as Western blotting, Western blotting and immunohistochemistry. These methods can detect the protein expression level of PEX5 and quantitatively analyze the expression level of PEX5. Through these methods, researchers can determine the function of PEX5 in cells and further study its association with disease.

Drug development for PEX5

PEX5 is a potential drug target because it is related to the occurrence of various diseases. At present, PEX5 drug development mainly includes inhibiting the activity of PEX5, inhibiting the binding of PEX5 to targets, and using PEX5 as a therapeutic target.

Inhibiting the activity of PEX5 can be used as a method to treat various tumors. For example, studies have found that inhibition of PEX5 can significantly inhibit the growth of breast and ovarian cancer in mice. In addition, inhibiting the activity of PEX5 can also inhibit cell adhesion and migration, thereby inhibiting tumor invasion and metastasis.

Another way to inhibit PEX5 is to inhibit PEX5 from binding to its target. Studies have found that PEX5 interacts with a variety of proteins, including Wnt, Notch and Hedgehog. By inhibiting the binding of PEX5 to these proteins, the signal transduction effect of PEX5 can be prevented, thereby inhibiting tumor proliferation and differentiation.

Using PEX5 as a therapeutic target is also a potential drug development approach. Studies have shown that PEX5 can bind to a variety of signaling molecules, including Wnt, Notch and Hedgehog. By utilizing PEX5 as a therapeutic target, tumor growth and metastasis can be inhibited.

in conclusion

PEX5 is a research subject that has attracted much attention because its mutations are associated with the occurrence of various diseases. PEX5 has complex structure and function and can regulate a variety of cellular processes. In addition, PEX5 also interacts with a variety of biological processes, so it can be used as a drug target or biomarker for treatment. Future research should further study the molecular mechanism of PEX5 and explore the role of PEX5 in treatment

Protein Name: Peroxisomal Biogenesis Factor 5

Functions: Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) (PubMed:7706321, PubMed:7719337, PubMed:7790377, PubMed:11336669, PubMed:12456682, PubMed:16314507, PubMed:21976670, PubMed:26344566, PubMed:11101887, PubMed:17157249, PubMed:17428317). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins (PubMed:12456682, PubMed:21976670, PubMed:26344566, PubMed:17157249). PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle (PubMed:11336669, PubMed:24662292)

The "PEX5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PEX5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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