PEX10: A promising drug target and biomarker for peroxisome biogenesis

Target Name: PEX10

NCBI ID: G5192

PEX10

PEX10: A promising drug target and biomarker for peroxisome biogenesis

Introduction

Peroxisomes are organelles responsible for the production of various bioactive molecules, including pro-inflammatory cytokines and toxins. Peroxisomal dysfunction has been implicated in various diseases, including neurodegenerative disorders, autoimmune diseases, and cancer. The peroxisome is also a dynamic organelle that requires several key factors for proper function, including Peroxisome Biogenesis Factor (PBF) 1. PBF1 is a protein that plays a crucial role in the biogenesis of peroxisomes and is expressed in various tissues. However, the precise mechanism of how PBF1 promotes peroxisome formation and function is not well understood.

PEX10, a heat-inducible gene that encodes a protein involved in the peroxisome-associated signaling pathway, has been identified as a potential drug target and biomarker for peroxisome dysfunction. In this article, we will discuss the biology of PEX10 and its potential as a drug target and biomarker.

biological background

Peroxisomes are organelles that are responsible for the production of various bioactive molecules, including pro-inflammatory cytokines and toxins. Peroxisomal dysfunction has been implicated in various diseases, including neurodegenerative disorders, autoimmune diseases, and cancer. The peroxisome is also a dynamic organelle that requires several key factors for proper function, including Peroxisome Biogenesis Factor (PBF) 1. PBF1 is a protein that plays a crucial role in the biogenesis of peroxisomes and is expressed in various tissues. However, the precise mechanism of how PBF1 promotes peroxisome formation and function is not well understood.

PEX10, a heat-inducible gene encoding a protein involved in peroxisome-associated signaling pathways, may be a drug target (or biomarker). In this article, we discuss the biology of PEX10 and explore its potential as a drug target or biomarker.

PEX10gene

The protein encoded by the PEX10 gene is a key component of a peroxisome-associated signaling pathway (PAS). PAS is a signaling pathway within cells responsible for the production of various biologically active molecules. By being synthesized within cells and localized to specific organelles or cytoplasmic matrices, PAS can trigger a series of biological processes, including cell proliferation, differentiation, and tumorigenesis. In tumorigenesis, abnormal activation of PAS is a major factor leading to tumorigenesis.

Regulation of PEX10 gene

The expression of PEX10 gene is regulated by a variety of transcription factors and regulatory factors. These factors include transcription factor-promoter interaction factors (T-PF), transcription factor-binding proteins (T-BPs), and RNA-binding proteins (RBPs). In addition, the gene expression of PEX10 is also regulated by regulatory elements, such as the promoter-enhancer of PEX10 (PEX10-AS).

PEX10 features

PEX10 plays a key role in various biological processes within cells. During the process of cell proliferation and differentiation, PEX10 interacts closely with PAS and participates in regulating the processes of cell cycle, cell proliferation and differentiation. In tumorigenesis, abnormal activation of PEX10 is a major factor leading to tumorigenesis.

Pharmacological significance of PEX10

Due to its critical role in cell proliferation, differentiation and tumorigenesis, PEX10 is considered a potential drug target. In particular, activation of PEX10 leads to prolongation of the S phase in the cell cycle, thereby increasing the risk of tumorigenesis. In addition, the interaction between PEX10 and PDGF (platelet-derived growth factor) has also attracted attention. Studies have shown that PEX10 can regulate the PDGF signaling pathway by phosphorylating PDGF receptor (PDGF-R), thereby affecting tumorigenesis.

Biological significance of PEX10

PEX10 plays a key role in cell proliferation, differentiation and tumorigenesis and is therefore considered a potential drug target. In particular, activation of PEX10 leads to prolongation of the S phase in the cell cycle, thereby increasing the risk of tumorigenesis. In addition, the interaction between PEX10 and PDGF (platelet-derived growth factor) has also attracted attention. Studies have shown that PEX10 can regulate the PDGF signaling pathway by phosphorylating PDGF receptor (PDGF-R), thereby affecting tumorigenesis.

Pharmacological significance of PEX10

Due to its critical role in cell proliferation, differentiation and tumorigenesis, PEX10 is considered a potential drug target. In particular, activation of PEX10 leads to prolongation of the S phase in the cell cycle, thereby increasing the risk of tumorigenesis. In addition, the interaction between PEX10 and PDGF (platelet-derived growth factor) has also attracted attention. Studies have shown that PEX10 can regulate the PDGF signaling pathway by phosphorylating PDGF receptor (PDGF-R), thereby affecting tumorigenesis.

Potential of PEX10 as a drug target or biomarker

Activation of PEX10 leads to prolongation of the S phase in the cell cycle, thereby increasing the risk of tumorigenesis. In addition, the interaction between PEX10 and PDGF (platelet-derived growth factor) has also attracted attention. Studies have shown that PEX10 can regulate the PDGF signaling pathway by phosphorylating PDGF receptor (PDGF-R), thereby affecting tumorigenesis.

Conclusion

PEX10 is a gene encoding a protein involved in the peroxisome-associated signaling pathway (PAS). PEX10 plays a key role in cell proliferation, differentiation and tumorigenesis. In addition, abnormal activation of PEX10 is a major factor leading to tumorigenesis. Therefore, PEX10 is a potential drug target (or biomarker) that can be used to treat many tumors by inhibiting its activity.

Protein Name: Peroxisomal Biogenesis Factor 10

Functions: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:24662292). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (PubMed:24662292). When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity)

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