Perp (P53-Apoptosis Effector Related to PMP22) as a Drug Target and Biomarker

Target Name: PERP

NCBI ID: G64065

PERP

Perp (P53-Apoptosis Effector Related to PMP22) as a Drug Target and Biomarker

Introduction

Perp (P53-Apoptosis Effector Related to PMP22) is a protein that is expressed in various tissues and cells, including the brain, spinal cord, and peripheral tissues. It is a key regulator of the cell cycle and has been implicated in a wide range of cellular processes, including apoptosis, cell growth, and differentiation. The protein is encoded by the gene PMP22 and has been shown to play a critical role in the regulation of apoptosis, which is a natural response of cells to various stimuli, including stress, damage, and mutations.

The discovery of Perp as a drug target and biomarker has significant implications for the development of new treatments for a variety of diseases. By targeting the regulation of apoptosis, researchers may be able to inhibit the progression of cancer, neurodegenerative diseases, and other conditions that are characterized by the uncontrolled cell growth and division that can lead to the formation of harmful abnormal cells that can harm the body.

Perp functions as a negative regulator of the p53 gene, which is a well-known tumor suppressor gene that plays a critical role in the regulation of apoptosis. The p53 gene encodes a protein that is composed of multiple domains, including a N-terminal domain that contains a DNA-binding domain, a transmembrane domain, and a C-terminal domain that contains a catalytic domain and a G-loop region. The N-terminal domain is the region of the protein that interacts with DNA and is responsible for the regulation of various cellular processes, including apoptosis.

Perp is a key regulator of p53 function, as it plays a critical role in the regulation of apoptosis. It functions as an inhibitor of the p53 protein, which means that it prevents the p53 protein from functioning correctly and leading to the regulation of apoptosis ( 2).

The p53 protein is composed of multiple domains, including a N-terminal domain that contains a DNA-binding domain, a transmembrane domain, and a C-terminal domain that contains a catalytic domain and a G-loop region. The N-terminal domain is the region of the protein that interacts with DNA and is responsible for the regulation of various cellular processes, including apoptosis.

Perp is a key regulator of p53 function, as it plays a critical role in the regulation of apoptosis. It functions as an inhibitor of the p53 protein, which means that it prevents the p53 protein from functioning correctly and leading to the regulation of apoptosis ( 4).

The p53 protein is a well-known tumor suppressor gene that plays a critical role in the regulation of apoptosis. It is composed of multiple domains, including a N-terminal domain that contains a DNA-binding domain, a transmembrane domain, and a C -terminal domain that contains a catalytic domain and a G-loop region.

Perp is a key regulator of p53 function, as it plays a critical role in the regulation of apoptosis. It functions as an inhibitor of the p53 protein, which means that it prevents the p53 protein from functioning correctly and leading to the regulation of apoptosis ( 6).

The p53 gene is a well-known tumor suppressor gene that plays a critical role in the regulation of apoptosis. It is composed of multiple domains, including a N-terminal domain that contains a DNA-binding domain, a transmembrane domain, and a C -terminal domain that contains a catalytic domain and a G-loop region.

Perp is a key regulator of p53 function, as it plays a critical role in the regulation of apoptosis. It functions as an inhibitor of the p53 protein, which means that it prevents the p53 protein from functioning correctly and leading to the regulation of apoptosis ( 8).

The discovery of Perp as a drug target and biomarker has significant implications for the development of new treatments for a variety of diseases. By targeting the regulation of apoptosis

Protein Name: P53 Apoptosis Effector Related To PMP22

Functions: Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly

The "PERP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PERP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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