PEX6: A Potential Drug Target and Biomarker for Peroxisomal Biogenesis Factor 6

Target Name: PEX6

NCBI ID: G5190

PEX6

PEX6: A Potential Drug Target and Biomarker for Peroxisomal Biogenesis Factor 6

Abstract: Peroxisomal biogenesis factor 6 (PEX6) is a protein that plays a crucial role in the biogenesis of peroxisomes, which are organelles responsible for storing and breaking down various types of toxins and other substances. In this article, we will discuss the potential drug target and biomarker properties of PEX6, as well as its current research status and potential therapeutic applications.

Introduction:

Peroxisomes are organelles that are present in all eukaryotic cells, and they play a vital role in the detoxification and Caten scissor folding process of various types of toxins and other substances. Peroxisomes are composed of two main components: a cytoplasmic region and a peroxisome membrane. The cytoplasmic region contains various enzymes and co-factors that are involved in the biogenesis of peroxisomes, while the peroxisome membrane is responsible for maintaining the structural integrity of the peroxisome and facilitating its interactions with the cytoplasm.

PEX6 is a protein that is expressed in various cell types and is involved in the biogenesis of peroxisomes. It is a 21-kDa protein that contains a catalytic active site, a nucleotide-binding oligomerization domain (N-terminus), a transmembrane region, and a cytoplasmic region. PEX6 plays a crucial role in the biogenesis of peroxisomes by helping to establish the structural organization and composition of the peroxisome membrane.

PEX6 functions as a scaffold protein that helps to maintain the peroxisome membrane stability. It does this by playing a key role in the formation of a trimeric complex between PEX6, peroxisome membrane protein (PMP)180, and peroxisome membrane protein (PMP)182. This trimeric complex is responsible for creating a stable pore in the peroxisome membrane that allows for the exchange of molecules between the cytoplasm and the peroxisome.

In addition to its role in peroxisome biogenesis, PEX6 has also been shown to have various physiological functions. For example, it has been shown to play a key role in cell signaling, as it has been shown to interact with various signaling molecules, including TGF -尾, Wnt, and Hedgehog. It has also been shown to be involved in various cellular processes, such as cell adhesion, migration, and invasion.

PEX6 has also been shown to have potential therapeutic applications. For example, it has been shown to be a potential drug target, as several studies have shown that inhibiting PEX6 activity can lead to the downregulation of peroxisomes and an increase in the levels of various types of toxins and other substances. Additionally, PEX6 has been shown to be a potential biomarker for various diseases, such as neurodegenerative diseases and cancer.

Current research status:

PEX6 research is ongoing, and there are several ongoing studies to determine its potential therapeutic applications. One of the most significant findings to have emerged from these studies is the potential of PEX6 inhibitors to treat various types of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

PEX6 inhibitors have been shown to increase the levels of peroxisomes in brain cells, which could potentially lead to the removal of toxins and other substances that are normally stored and eliminated by the peroxisome. Additionally, these inhibitors have been shown to reduce the levels of reactive oxygen species (ROS), which are highly reactive molecules that can cause damage to brain cells and contribute to the development of neurodegenerative diseases.

Another significant finding in

Protein Name: Peroxisomal Biogenesis Factor 6

Functions: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed:16314507, PubMed:16854980, PubMed:21362118, PubMed:29884772). Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (PubMed:29884772). Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (PubMed:29884772)

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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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