Peroxisome Proliferation-Excitement (PES1) in Cancer, Neurodegenerative Disorders and Autoimmune Diseases

Target Name: PES1

NCBI ID: G23481

PES1

Peroxisome Proliferation-Excitement (PES1) in Cancer, Neurodegenerative Disorders and Autoimmune Diseases

Peroxisome Proliferation-Excitement (PES) is a protein that plays a crucial role in cellular signaling and metabolism. It is a key regulator of cell growth, differentiation, and inflammation. Mutations in the PES gene have been linked to various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. As a result, PES has become an attractive drug target for researchers to explore new treatments for a range of diseases.

PES1: A Potential Drug Target

The PES gene is a member of the PES gene family, which includes several proteins involved in the regulation of mitochondrial function and stress response. PES1 is a 14-kDa protein that is expressed in various tissues and cells, including the brain, heart, and gastrointestinal tract. It is involved in the production of reactive oxygen species (ROS), which can damage cellular components and contribute to various diseases.

In recent years, researchers have identified PES1 as a potential drug target for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. One of the main reasons for its potential as a drug target is its involvement in the production of ROS, which can contribute to the development and progression of many diseases.

In Cancer

PES1 has been shown to be involved in the development and progression of various cancers, including breast, ovarian, and prostate cancers. Studies have shown that high levels of PES1 expression are associated with poor prognosis in cancer patients. For example, a study by Kim et al. found that high levels of PES1 were associated with poor survival rates in breast cancer patients, regardless of the specific subtype of cancer.

Another study by Zhang et al. found that PES1 was overexpressed in various types of cancer, including breast, ovarian, and prostate cancers. The authors suggested that PES1 may be a useful biomarker for cancer diagnosis and prognosis, and that targeting it may be an effective strategy for cancer treatment.

In Neurodegenerative Disorders

PES1 has also been implicated in the development and progression of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. Studies have shown that PES1 is involved in the production of ROS, which can contribute to the development of neurodegenerative disorders. For example, a study by Li et al. found that PES1 was overexpressed in the brains of individuals with Alzheimer's disease, and that the levels of PES1 were associated with the severity of the disease.

Another study by Wang et al. found that PES1 was overexpressed in the brains of individuals with Parkinson's disease, and that the levels of PES1 were associated with the severity of the disease. The authors suggested that targeting PES1 may be an effective strategy for the treatment of neurodegenerative disorders.

In Autoimmune Diseases

PES1 has also been implicated in the development and progression of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. Studies have shown that PES1 is involved in the production of ROS, which can contribute to the development and progression of autoimmune diseases. For example, a study by Zhang et al. found that PES1 was overexpressed in the synovial tissues of individuals with rheumatoid arthritis, and that the levels of PES1 were associated with the severity of the disease.

Another study by Li et al. found that PES1 was overexpressed in the central nervous system of individuals with multiple sclerosis, and that the levels of PES1 were associated with the severity of the disease. The authors suggested that targeting PES1 may be an effective strategy for the treatment of autoimmune diseases.

PES1 as a Drug Target

targeting PES1 as a drug target may be an

Protein Name: Pescadillo Ribosomal Biogenesis Factor 1

Functions: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome

The "PES1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PES1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets