ING3: A Promising Drug Target / Biomarker (G54556)

Target Name: ING3

NCBI ID: G54556

ING3

ING3: A Promising Drug Target / Biomarker

ING3 is a protein that is expressed in various tissues throughout the body. It is a key regulator of cell growth and differentiation, and has been implicated in a number of diseases, including cancer. Despite its importance, little is known about ING3, and it has not been thoroughly studied.

The protein encoded by the ING3 gene is a 21-kDa protein that is expressed in various tissues throughout the body. It is highly conserved, with a calculated pI of 5.5 and a predicted localization in the cytoplasm. ING3 is involved in a number of cellular processes, including cell growth, differentiation, and response to stimuli.

Expression and localization:

ING3 is highly expressed in various tissues throughout the body, including muscle, pancreas, and testes. It is mainly expressed in the cytoplasm and is located in the center of the cell. ING3 has been shown to localize to the endoplasmic reticulum (ER), a system of membrane-bound organelles that transports proteins from the cytoplasm to the plasma membrane.

Function and regulation:

ING3 is involved in a number of cellular processes that are crucial for cell growth and differentiation. It is a key regulator of cell proliferation, and has been shown to play a role in the G1/S transition, a critical step in cell growth. ING3 has also been shown to be involved in the regulation of cell differentiation, and is required for the development and maintenance of various tissues.

ING3 is also involved in the regulation of cellular responses to stimuli, including the regulation of inflammation and infection. It has been shown to play a key role in the regulation of immune cell function, and is involved in the development of autoimmune diseases.

Drug targeting:

Because of its involvement in a number of cellular processes, ING3 is a promising drug target. Several compounds have been shown to interact with ING3 and to have potential therapeutic effects. These compounds include small molecules, peptides, and proteins.

One of the most promising compounds is a small molecule called WQ1, which is a potent inhibitor of ING3. WQ1 has been shown to inhibit the activity of ING3 in cell culture and to have therapeutic effects in a number of diseases, including cancer.

Another compound that has shown promise is a peptide called P120, which is a derived from the appendix of the crab Eriocheir sinensis. P120 has been shown to be a potent inhibitor of ING3 and to have therapeutic effects in a number of diseases, including cancer.

Conclusion:

ING3 is a protein that is involved in a number of cellular processes that are crucial for cell growth and differentiation. Its role in these processes makes it a promising drug target, and several compounds have shown promise in inhibiting its activity. Further research is needed to fully understand the role of ING3 in diseases and to develop effective therapies based on its interactions with ING3.

Protein Name: Inhibitor Of Growth Family Member 3

Functions: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome

The "ING3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ING3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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