CCDC40: A Potential Drug Target and Biomarker (G55036)

Target Name: CCDC40

NCBI ID: G55036

CCDC40

CCDC40: A Potential Drug Target and Biomarker

CDC40 (Coiled-coil domain containing 40) is a protein that has been identified as a potential drug target and biomarker. It is a member of the cryptic C domain family, which is known for their ability to interact with various signaling pathways, including TGF-β, NF-kappa-B, and PI3K. CDC40 has been shown to play a critical role in several physiological processes, including cell adhesion, migration, and invasion.

CDC40 Expression and Significance

CDC40 is a 21-kDa protein that is expressed in various tissues and cell types. It is highly conserved throughout the body and has been shown to be involved in several signaling pathways, including TGF-β, NF-kappa-B, and PI3K. TGF-β is a well-known signaling pathway that regulates cell growth, differentiation, and survival, and it is known to play a critical role in the regulation of cell adhesion and migration.

CDC40 has been shown to be involved in the TGF-β signaling pathway by regulating the activity of the transcription factor, SMAD2. SMAD2 is a key transcription factor that is known to play a critical role in the regulation of cell adhesion and migration. By regulating the activity of SMAD2, CDC40 has been shown to contribute to the regulation of cellular processes that are critical for normal development and growth.

CDC40 has also been shown to be involved in the PI3K signaling pathway, which is involved in the regulation of cell signaling and inflammation. The PI3K signaling pathway is known to play a critical role in the regulation of cell survival and proliferation, and it is known to be involved in the regulation of many cellular processes, including inflammation, pain, and survival.

CDC40 has also been shown to be involved in the regulation of cell adhesion and migration. Adhesion is the process by which cells stick together to form tissues and organs, and it is critical for the development and maintenance of tissues and organs. CDC40 has been shown to play a critical role in the regulation of cell adhesion by regulating the activity of the adhesion molecule, E-cadherin.

CDC40 has also been shown to be involved in the regulation of cell migration. Migration is the process by which cells move from one location to another, and it is critical for the development and maintenance of tissues and organs. CDC40 has been shown to play a critical role in the regulation of cell migration by regulating the activity of the migration tensor, which is a protein that is involved in the regulation of cell movement.

CDC40 as a Potential Drug Target

CDC40 has been shown to be a potential drug target by several studies. One study identified a potential drug target for CDC40 by using a bioinformatics screen to identify a gene that was highly conserved and was expressed in various tissues and cell types. The identified gene was shown to encode a protein that was similar to CDC40, but with some differences.

Another study demonstrated that a small molecule inhibitor was able to inhibit the activity of CDC40 and inhibit the migration of cancer cells. This suggests that CDC40 may be a promising drug target for cancer therapy.

CDC40 as a Biomarker

CDC40 has also been shown to be a potential biomarker for several diseases. For example, one study identified a correlation between the level of CDC40 and the level of the protein, E-cadherin, in breast cancer cells. This suggests that CDC40 may be a promising biomarker for breast cancer.

Another study demonstrated that CDC40 was expressed in the primary cancerous tissue and was associated with the development

Protein Name: Coiled-coil Domain Containing 40

Functions: Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131974). Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 (PubMed:21131974)

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