Targeting PP2CA: A Promising Strategy for Drug Development (G5515)

Target Name: PPP2CA

NCBI ID: G5515

PPP2CA

Targeting PP2CA: A Promising Strategy for Drug Development

PP2CA (PP2-Adenosine Monophosphate Transferase-Catalyzed Adenosine Monophosphate Transfer) is a protein that plays a crucial role in cellular signaling. It is a key enzyme in the P2A signaling pathway, which is involved in various cellular processes, including cell signaling, cell division, and neurotransmission. PP2CA is also known as ADP-ribosylated RNA (ARRNA) kinase (PRK) and is composed of three subunits: PRK1, PRK2, and PRK3.

The P2A signaling pathway is a complex signaling pathway that involves the transfer of adenosine monophosphate (AMP) to various cellular signaling pathways. AMP is a second messenger that plays a crucial role in cellular signaling by regulating various cellular processes. The P2A signaling pathway is involved in the regulation of cell signaling, cell division, neurotransmission, and many other cellular processes.

PP2CA is a key enzyme in the P2A signaling pathway that is responsible for the transfer of AMP to the P2A binding protein (P2ABP). P2ABP is a protein that can bind to various signaling pathways, including the P2A signaling pathway. The P2A signaling pathway is composed of several protein components, including PP2CA, P2ABP, and several other proteins.

PP2CA is a protein that is expressed in various tissues and cells, including the brain, heart, and gastrointestinal tract. It is also involved in the regulation of various cellular processes, including cell signaling, cell division, neurotransmission, and many other cellular processes.

Drug Targeting

PP2CA is a drug target that is being targeted by various researchers for its potential therapeutic applications. The P2A signaling pathway is a complex signaling pathway that is involved in various cellular processes, including cell signaling, cell division, neurotransmission, and many other cellular processes. The P2A signaling pathway is composed of several protein components, including PP2CA, P2ABP, and several other proteins.

PP2CA is a key enzyme in the P2A signaling pathway that is responsible for the transfer of AMP to the P2ABP protein. The P2ABP protein can bind to various signaling pathways, including the P2A signaling pathway. The P2A signaling pathway is composed of several protein components, including PP2CA, P2ABP, and several other proteins.

Targeting PP2CA

The P2A signaling pathway is a complex signaling pathway that is involved in various cellular processes, including cell signaling, cell division, neurotransmission, and many other cellular processes. The P2A signaling pathway is composed of several protein components, including PP2CA, P2ABP, and several other proteins.

PP2CA is a key enzyme in the P2A signaling pathway that is responsible for the transfer of AMP to the P2ABP protein. The P2ABP protein can bind to various signaling pathways, including the P2A signaling pathway. The P2A signaling pathway is composed of several protein components, including PP2CA, P2ABP, and several other proteins.

Targeting PP2CA is a promising strategy for the development of new therapeutic applications. Several researchers have shown that targeting PP2CA can be effective in treating various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders.

Biomarker

PP2CA is also known as ADP-ribosylated RNA (ARRNA) kinase (PRK) and is composed of three subunits: PRK1, PRK2, and PRK3. PRK1 is the catalytic subunit, which is responsible for the transfer of AMP to the P2ABP protein. PRK2 and PRK3 are the subunit 2 and subunit 3, which are involved in the regulation of various cellular processes.

PP2CA is a protein that is expressed in various tissues and cells, including the brain, heart, and gastrointestinal tract. It is also involved in the regulation of various cellular processes, including cell signaling, cell division, neurotransmission, and many other cellular processes.

Biomarker Research

PP2CA is a protein that is involved in various cellular processes, including

Protein Name: Protein Phosphatase 2 Catalytic Subunit Alpha

Functions: PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53 (PubMed:17245430). Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (PubMed:30513302). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity)

The "PPP2CA Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PPP2CA comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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