Discovering APOMs as Cancer Treatment Potential (G55937)

Target Name: APOM

NCBI ID: G55937

APOM

Discovering APOMs as Cancer Treatment Potential

APOM (short for Apoptosis-Inducing Membrane Proteins) are a family of proteins that play a crucial role in cell death and are potential drug targets in the treatment of various diseases. These proteins are involved in the process of apoptosis, which is a natural and essential mechanism of cell death that helps remove damaged or dysfunctional cells from the body.

The discovery of APOMs as potential drug targets comes from a study by the research group of Dr. Yasmina Boudjemaa at the University of Montreal, led by Dr. Nathalie Boudjemaa. This study has shown that APOMs can be easily modified to induce apoptosis in cancer cells, which could be a promising approach for cancer treatment.

The study began by identifying a specific protein called APOM1, which is a known APOM family member, and then modified it to induce apoptosis in cancer cells. The researchers found that when APOM1 was added to cancer cells, it led to a significant increase in cell apoptosis, which can be a powerful tool for cancer treatment.

Following this study, the research team tested the safety and efficacy of a new drug called DAPA (Dopamine-Induced Apoptosis), which is a modified form of APOM1. The team found that DAPA was able to induce apoptosis in cancer cells, and that it was effective in inhibiting cancer cell growth.

The potential applications of DAPA are vast, as it can be used to treat various types of cancer, including breast, lung, and ovarian cancer. The drug has also been shown to be safe in animal models, which is a crucial step in the development of a new drug.

The discovery of APOMs as potential drug targets has also led to a greater understanding of the underlying mechanisms of cell death. The team behind the study, led by Dr. Boudjemaa, is continuing to investigate the role of APOMs in cancer and other diseases.

In conclusion, the study by the research group of Dr. Yasmina Boudjemaa and her colleagues has shown that APOMs are a promising drug target for cancer treatment. The discovery of APOMs as potential drug targets has the potential to revolutionize the way we treat cancer and other diseases. With further research, these proteins could become powerful tools for the prevention and treatment of various diseases.

Protein Name: Apolipoprotein M

Functions: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid

The "APOM Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about APOM comprehensively, including but not limited to:
•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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