APOOP2: A Potential Drug Target and Biomarker (G100129005)

Target Name: APOOP2

NCBI ID: G100129005

APOOP2

Other Name(s): apolipoprotein O pseudogene 2 | Apolipoprotein O pseudogene 2

APOOP2: A Potential Drug Target and Biomarker

Apoptosis, the process of natural cell death, has been linked to various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The regulation of apoptosis is a critical immune response, and dysregulated apoptosis has been implicated in the development and progression of these diseases. The protein APOOP2, also known as caspase-34, is a key player in the regulation of apoptosis and has been identified as a potential drug target and biomarker for various diseases.

APOOP2: Structure and Function

APOOP2 is a 24-kDa protein that is expressed in various tissues, including brain, heart, and pancreas. It is a member of the caspase family, which includes proteins that play a crucial role in the regulation of apoptosis. The structure of APOOP2 consists of a 215 amino acid residue protein that contains a unique N-terminal region, a 22 amino acid residue extension, and a 193 amino acid extension.

The N-terminal region of APOOP2 contains a 20 amino acid residue transmembrane domain, which is known as the C-terminal region, and is involved in the regulation of apoptosis by various mechanisms. The 22 amino acid residue extension is located within the intracellular domain and is involved in the formation of a complex with other proteins, including caspase-34 itself. The 193 amino acid extension is located within the cytoplasmic domain and is involved in the regulation of apoptosis by the B-cell receptor (BCR), which is a protein that plays a crucial role in the development of cancer.

APOOP2 is involved in the regulation of apoptosis through several mechanisms. Firstly, it is involved in the formation of the apoptotic cell death complex (ACDE), which includes various proteins that play a crucial role in the regulation of apoptosis, including caspase-34 itself. Secondly, it is involved in the regulation of BCR-mediated apoptosis, which is a critical immune response that helps eliminate cancer cells.

APOOP2 has also been shown to be a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that high levels of APOOP2 are associated with poor prognosis in patients with pancreatic ductal adenocarcinoma, a type of pancreatic cancer. Additionally,APOOP2 has been shown to be involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

Potential Therapeutic Applications

The potential therapeutic applications of APOOP2 as a drug target and biomarker are vast. Firstly, APOOP2 has been shown to be involved in the regulation of apoptosis, which is a critical immune response that helps eliminate cancer cells. Therefore, drugs that target APOOP2 may be effective in treating various cancers, including breast, lung, and ovarian cancers.

Secondly, APOOP2 has been shown to be involved in the regulation of BCR-mediated apoptosis, which is a critical immune response that helps eliminate cancer cells. Therefore, drugs that target APOOP2 may be effective in treating various types of cancer, including leukemia and lymphoma.

Thirdly, APOOP2 has been shown to be involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Therefore, drugs that target APOOP2 may be effective in treating these diseases and improving quality of life.

Finally, APOOP2 has also been shown to be involved in the regulation of inflammation, which is a critical immune response that can contribute to the development of various diseases, including autoimmune disorders. Therefore, drugs that target APOOP2 may be effective in treating

Protein Name: Apolipoprotein O Pseudogene 2

The "APOOP2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about APOOP2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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