Unlocking the Potential of KAT14 as a Drug Target and Biomarker

Target Name: KAT14

NCBI ID: G57325

KAT14

Unlocking the Potential of KAT14 as a Drug Target and Biomarker

Introduction

Kallikrein-related peptidases (KAPs), also known as cathepsins, are a family of enzymes that regulate various cellular processes. The KAT14 gene, located on chromosome 19, encodes for a protein known as KAT14 (Kallikrein-Related Peptidase 2). This protein has been shown to participate in various cellular signaling pathways, including inflammation, cell death, and metabolism. As a result, KAT14 has gained significant interest as a potential drug target and biomarker.

The Druggable Potential of KAT14

KAT14 has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes. The KAT14 protein is a member of the Kallikrein-related peptidases (KAPs), a family of 13 structurally similar enzymes that share a conserved catalytic core. These enzymes catalyze the hydrolysis of a specific peptidic bond between the N-terminus of the target protein and its Asp residue.

KAT14 has been shown to play a critical role in the cellular processes, including inflammation, cell death, and metabolism regulation. For instance, KAT14 has been shown to be involved in the regulation of inflammation and cell death.

Inflammation is a critical response of the immune system to pathogens and tissue damage. The production of pro-inflammatory cytokines, such as TNF-伪, IL-1尾, and IL-6, is a crucial part of this response. KAT14 has been shown to be involved in the regulation of the production and degradation of these cytokines.

In addition to its role in inflammation, KAT14 has also been shown to be involved in cell death. The regulation of cell death is a critical process that ensures the maintenance of cellular homeostasis and the development of tissues. role in this process by regulating the production and degradation of pro-apoptotic cytoskeletal proteins, such as Bcl-2 and p53.

Finally, KAT14 has also been shown to be involved in metabolism. The regulation of protein metabolism is essential for maintaining cellular homeostasis and for the production of critical proteins required for cellular processes. KAT14 has also been shown to play a critical role in this process by regulating the degradation of various proteins, including the transcription factor, p53.

Biomarker Potential of KAT14

The potential of KAT14 as a biomarker has also been shown. The KAT14 protein has been shown to have diagnostic value in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

For instance, KAT14 has been shown to be involved in the regulation of cancer cell proliferation. The production of pro-inflammatory cytokines, such as TNF-伪, IL-1尾, and IL-6, is a crucial part of this process. KAT14 has been shown to play a critical role in the regulation of the production and degradation of these cytokines, which may contribute to the regulation of cancer cell proliferation.

In addition to its role in cancer, KAT14 has also been shown to be involved in the regulation of neurodegenerative diseases. The regulation of the production and degradation of neurotransmitters, such as dopamine and serotonin, is essential for maintaining cellular homeostasis and for the proper functioning of nervous system. KAT14 has

Protein Name: Lysine Acetyltransferase 14

Functions: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle

The "KAT14 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KAT14 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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