Discovering STIM1: A Protein with Potential as A Drug Target Or Biomarker

Target Name: STIM1

NCBI ID: G6786

STIM1

Discovering STIM1: A Protein with Potential as A Drug Target Or Biomarker

Single-chain inositol trisphosphate (STIM1) is a protein that plays a crucial role in intracellular signaling. It is a key regulator of various cellular processes, including intracellular calcium levels, neurotransmitter release, and cell survival. STIM1 is also involved in the regulation of ion channels, including the voltage-dependent K+ channels that play a major role in neurotransmission.

The discovery of STIM1 as a drug target or biomarker has significant implications for the development of new treatments for various neurological and psychiatric disorders. In this article, we will explore the biology of STIM1, its functions as a drug target, and the current research on its potential as a biomarker.

Structure and Function

STIM1 is a single-chain protein that consists of 214 amino acid residues. It has a molecular weight of 21.1 kDa and a pre-expression level of 11.5 kDa. STIM1 is primarily localized to the endoplasmic reticulum (ER) and is also found in the cytoplasm. It has a partial pI of 6.5 and a predicted localization in the ER, which is consistent with its functions as a regulator of intracellular signaling.

STIM1 is involved in various cellular signaling pathways, including intracellular calcium signaling, neurotransmitter release, and cell survival. It is a critical regulator of the voltage-dependent K+ channels, which play a major role in neurotransmission. These channels are involved in the regulation of neuronal excitability and are critical for the transmission of action potentials, which are the changes in the electrical potential across the cell membrane that result from the influx of neurotransmitters.

In addition to its role in intracellular signaling, STIM1 is also involved in the regulation of ion channels. It has been shown to regulate the activity of several types of ion channels, including the Na+/K+-ATPase and the calcium channel. These channels are involved in the regulation of various cellular processes, including muscle contractions, neurotransmission, and intracellular signaling.

As a drug target, STIM1 has significant potential for the development of new treatments for various neurological and psychiatric disorders. Its functions as a regulator of intracellular signaling and ion channels make it an attractive target for small molecules that can modulate its activity. Additionally, its localization in the ER makes it a potential candidate for drug targeting to specific cellular compartments.

Current Research

The development of new treatments for neurological and psychiatric disorders depends on the identification of reliable drug targets. STIM1 has been shown to be involved in the regulation of various cellular processes, making it an attractive target for small molecules. Several studies have investigated the potential of small molecules as modulators of STIM1 activity.

One of the most promising small molecules for modulating STIM1 activity is curcumin, which is an antioxidant that is found in turmeric, a spice commonly used in Indian cuisine. Curcumin has been shown to have anti-inflammatory and neuroprotective effects, and may be a potential therapeutic agent for various neurological and psychiatric disorders.

Another small molecule that has been shown to modulate STIM1 activity is rapamycin, which is an immunosuppressant drug used to prevent the rejection of transplanted organs. Rapamycin has been shown to inhibit the activity of several transcription factors, including STIM1, and may be a potential therapeutic agent for the treatment of various neurological and psychiatric disorders.

In addition to curcumin and rapamycin, several other small molecules have been shown to modulate STIM1 activity. These molecules include resveratrol, a natural compound found in red wine and grapes, and 尾-amyloid, a protein that is involved in the development of Alzheimer's disease.

Conclusion

In conclusion, STIM1 is a protein that plays a crucial role in intracellular signaling and has significant potential as a drug target or biomarker. Its functions as a regulator of intracellular signaling and ion channels make it an attractive target for small molecules that can modulate its activity . Current research is focused on the development of new treatments for various neurological and psychiatric disorders using small molecules that can modulate STIM1 activity. Further studies are needed to determine the full potential of STIM1 as a drug target or biomarker.

Protein Name: Stromal Interaction Molecule 1

Functions: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19249086, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:26322679, PubMed:25326555, PubMed:28219928). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 (PubMed:16208375, PubMed:16537481). Involved in enamel formation (PubMed:24621671). Activated following interaction with STIMATE, leading to promote STIM1 conformational switch (PubMed:26322679)

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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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