TRPV4: A Protein Involved in Neurotransmitter Signaling, Pain Perception and Body Temperature

Target Name: TRPV4

NCBI ID: G59341

TRPV4

TRPV4: A Protein Involved in Neurotransmitter Signaling, Pain Perception and Body Temperature

TRPV4, also known as Transient receptor potential cation channel subfamily V member 4, is a protein that plays a crucial role in cellular signaling. It is a highly conserved gene that is expressed in many different tissues and cells, including the nervous system, endocrine system, and uveal system.

TRPV4 is a member of the TRPV family, which is characterized by the presence of a unique transmembrane ion channel that is responsible for mediating the transport of certain ions into and out of cells. This channel is known as a cation channel, and it is involved in a wide range of physiological processes, including neurotransmitter signaling, pain perception, and body temperature.

TRPV4 is a 22-kDa protein that is expressed in the brain and other tissues. It is primarily localized to the dendrites of neurons and is involved in the regulation of neurotransmitter release. It is also involved in the modulation of pain perception and body temperature, and it has been implicated in a number of diseases, including epilepsy, bipolar disorder, and neurodegenerative diseases.

One of the key functions of TRPV4 is its role in neurotransmitter signaling. When a neurotransmitter binds to its transmembrane ion channel, it causes a change in the electrical potential across the membrane. This change in potential is then transduced into a change in the amount of neurotransmitter released. This process is critical for the regulation of neurotransmitter signaling and is a key mechanism by whichTRPV4 contributes to the complex neural network that underlies brain function.

In addition to its role in neurotransmitter signaling, TRPV4 is also involved in the regulation of pain perception and body temperature. It has been shown to play a key role in the modulation of pain sensitivity and in the regulation of body temperature during physical activity.

TRPV4 has also been implicated in a number of diseases, including epilepsy, bipolar disorder, and neurodegenerative diseases. For example, studies have shown that TRPV4 is overexpressed in individuals with epilepsy and that it is involved in the regulation of neurotransmitter release in this condition. Similarly, TRPV4 has been shown to be involved in the regulation of body temperature in individuals with bipolar disorder.

Given its involvement in a wide range of physiological processes, TRPV4 is an attractive drug target and a potential biomarker for a number of diseases.TRPV4 has been shown to be involved in the regulation of neurotransmitter signaling, pain perception, and body temperature, and it is potential target for drugs that can modulate these processes. Further studies are needed to fully understand the role of TRPV4 in these processes and to develop effective treatments for TRPV4-related diseases.

Protein Name: Transient Receptor Potential Cation Channel Subfamily V Member 4

Functions: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040, PubMed:29899501). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18826956, PubMed:18695040, PubMed:25256292, PubMed:20037586, PubMed:21964574). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PubMed:29899501)

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