SDHA: A Potential Drug Target for Blood Clots (G6389)

Target Name: SDHA

NCBI ID: G6389

SDHA

SDHA: A Potential Drug Target for Blood Clots

SDHA, or Flavoprotein subunit of complex II, is a protein that plays a crucial role in the function of the blood clotting system. It is a subunit of the complex II protein, which is responsible for the formation of blood clots after a blood vessel has been damaged. SDHA helps to regulate the activity of the complex II protein, and is therefore a potential drug target or biomarker for various blood clot-related conditions.

The blood clotting system is a complex process that involves the formation of a blood clot to stop bleeding when a blood vessel is damaged or ruptured. The complex II protein is a key regulator of this process, and is responsible for the formation of the blood clot . SDHA is a subunit of complex II that helps to regulate the activity of the protein.

SDHA has been shown to be involved in the regulation of various clotting factors, including the protein fragment GPIb/IXa (also known as GPIIb/IIIa), which is involved in the formation of the outer layer of the blood clot. GPIb/IXa is a critical factor in the formation of blood clots, and is often targeted by anticoagulants. SDHA has been shown to regulate the activity of GPIb/IXa, which suggests that it may be a potential drug target or biomarker for blood clot-related conditions.

In addition to its role in regulating GPIb/IXa, SDHA is also involved in the regulation of other clotting factors, including the protein fragment CD40 (also known as PDGFR-1). CD40 is a critical regulator of inflammation and immune responses, and is involved in the formation of blood clots. SDHA has been shown to regulate the activity of CD40, which suggests that it may be a potential drug target or biomarker for inflammation-related conditions.

The role of SDHA in the regulation of the blood clotting system is also of interest in the context of hereditary thrombosis. Hereditary thrombosis is a genetic disorder that is characterized by the increased risk of thrombosis. Many hereditary thrombosis conditions are caused by mutations in the SDHA gene, which result in the production of an abnormal form of the protein. These mutations can then cause the blood clotting system to malfunction, leading to the development of thrombosis.

In conclusion, SDHA is a protein that plays a crucial role in the function of the blood clotting system. Its regulation of the complex II protein, and its involvement in the regulation of various clotting factors, suggest that it may be a potential drug target or biomarker for various blood clot-related conditions. Further research is needed to fully understand the role of SDHA in the regulation of the blood clotting system, and to determine its potential as a drug target or biomarker.

Protein Name: Succinate Dehydrogenase Complex Flavoprotein Subunit A

Functions: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:24781757). Can act as a tumor suppressor (PubMed:20484225)

The "SDHA Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SDHA comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets