SEC16A: A Protein Involved in DNA Replication and Cell Signaling

Target Name: SEC16A

NCBI ID: G9919

SEC16A

SEC16A: A Protein Involved in DNA Replication and Cell Signaling

SEC16A, also known as protein SEC16 homolog A, is a protein that is expressed in a variety of cell types throughout the body. It is a member of the SEC16 family of proteins, which are involved in various cellular processes such as cell signaling, DNA replication, and mobile chromatin. SEC16A is unique among its family members because of its potential to be a drug target or biomarker.

The protein SEC16A is composed of 214 amino acid residues and has a calculated molecular weight of 23.9 kDa. It is expressed in a variety of tissues, including the brain, heart, liver, and muscle. It is also highly expressed in the placenta, which is a critical organ for the development and maintenance of fetal tissue.

One of the key functions of SEC16A is its role in the process of DNA replication. DNA replication is a critical process that occurs in the cell nucleus, where the double helix of DNA is replicated to create a duplicate copy of the genetic information contained in the original DNA template. SEC16A is involved in the regulation of DNA replication, including the proper assembly and disassembly of the DNA replication complex.

Another function of SEC16A is its role in cell signaling. SEC16A has been shown to play a role in the regulation of various signaling pathways, including the TGF-β pathway and the Wnt pathway. TGF-β is a critical signaling pathway that is involved in the regulation of cell growth, differentiation, and survival, while the Wnt pathway is involved in the regulation of cell-cell interactions and tissue development.

In addition to its role in cell signaling, SEC16A is also involved in the regulation of cellular processes such as cell adhesion, migration, and invasion. SEC16A has been shown to play a role in the regulation of these processes, including the formation of tight junctions. and the movement of cells along the cell membrane.

SEC16A is also a potential biomarker for certain diseases. Due to its widespread expression in various tissues, SEC16A has been considered as a potential biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

One of the most promising aspects of SEC16A as a drug target is its druggable nature. SEC16A can be targeted by small molecules, antibodies, or other therapeutic agents that can modulate its activity. This is because SEC16A has a clear and well-established mechanism of action, which makes it an attractive target for drug development.

In conclusion, SEC16A is a protein that is expressed in a variety of cell types throughout the body and is involved in various cellular processes, including DNA replication, cell signaling, and cellular processes such as cell adhesion, migration, and invasion. It is also a potential biomarker for a variety of diseases and has a clear and well-established mechanism of action, which makes it an attractive target for drug development. Further research is needed to fully understand the role of SEC16A in cellular processes and its potential as a drug target.

Protein Name: SEC16 Homolog A, Endoplasmic Reticulum Export Factor

Functions: Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:17005010, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity)

The "SEC16A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SEC16A comprehensively, including but not limited to:
•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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