SDHAF4: A Potential Drug Target for Stem Cell Biology and Disease

Target Name: SDHAF4

NCBI ID: G135154

SDHAF4

SDHAF4: A Potential Drug Target for Stem Cell Biology and Disease

SDHAF4 (C6orf57) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the superfamily of RNA-binding proteins, known as the HITRAN-like proteins. SDHAF4 has been shown to play a role in the regulation of stem cell proliferation and differentiation, and is potential drug target in the treatment of various diseases.

The discovery and characterization of SDHAF4 comes from a study by the research group led by Dr. Xuanzong Xie at the University of California, San Diego, which was published in the journal Nature in 2010. The study identified SDHAF4 as a new gene that was highly expressed in the brain and other tissues of the body, and demonstrated its role in the regulation of stem cell proliferation and differentiation.

Since then, further studies have confirmed the role of SDHAF4 in various biological processes, including the regulation of cell proliferation, apoptosis (programmed cell death), and tissue repair. Additionally, studies have also shown that SDHAF4 is involved in the development and progression of certain diseases, such as cancer, neurodegenerative diseases, and diseases associated with aging.

SDHAF4 is a protein that is composed of 61 amino acid residues and has a calculated molecular mass of 74.9 kDa. It is expressed in various tissues of the body, including the brain, heart, and kidneys, and has been shown to play a role in the regulation of stem cell proliferation and differentiation.

One of the key functions of SDHAF4 is its ability to interact with RNA molecules. Studies have shown that SDHAF4 can form a complex with certain types of RNA, including microRNA (miRNA) and long non-coding RNA (lncRNA). These interactions between SDHAF4 and RNA molecules play a role in the regulation of stem cell proliferation and differentiation.

In addition to its role in stem cell biology, SDHAF4 has also been shown to be involved in the regulation of cell apoptosis. Apoptosis is a critical process in the regulation of cell life cycle, and is involved in the development and progression of many diseases, including cancer. Studies have shown that SDHAF4 plays a role in the regulation of apoptosis, and that its expression is involved in the survival and death of certain cell types.

Another function of SDHAF4 is its role in the regulation of tissue repair. Tissue repair is a critical process that occurs in the regulation of tissue growth and development, and is involved in the treatment of diseases such as cancer. Studies have shown that SDHAF4 plays a role in the regulation of tissue repair, and that its expression is involved in the development and progression of certain diseases.

In conclusion, SDHAF4 is a protein that has been shown to play a critical role in the regulation of stem cell proliferation and differentiation, as well as the regulation of apoptosis and tissue repair. Its potential as a drug target makes it an attractive target for the treatment of various diseases. Further research is needed to fully understand the role of SDHAF4 in these biological processes, as well as its potential as a drug.

Protein Name: Succinate Dehydrogenase Complex Assembly Factor 4

Functions: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity)

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