ACOT1: Potential Drug Target for Alzheimer's (G641371)

Target Name: ACOT1

NCBI ID: G641371

ACOT1

ACOT1: Potential Drug Target for Alzheimer's

ACOT1 (Alzheimer's disease-associated protein 1) is a protein that is expressed in the brain and has been implicated in the development and progression of Alzheimer's disease. The protein is a member of the superfamily of transmembrane proteins, which are a type of protein that spans the membrane of the cell and extend into the space between the cell and its surroundings.

ACOT1 is expressed in the brain and has been shown to be involved in the formation of neurofibrillary tangles, which are a hallmark of Alzheimer's disease. These tangles are composed of abnormal aggregates of the protein tau and beta-amyloid, which are thought to contribute to the destruction of nerve cells in the brain that is characteristic of Alzheimer's disease.

In addition to its involvement in the formation of neurofibrillary tangles, ACOT1 has also been shown to be involved in the regulation of the production of neurotransmitters, which are chemical messengers that transmit signals between cells. This protein has been shown to interact with the neurotransmitter dopamine and may play a role in the regulation of dopamine release and uptake in the brain.

Furthermore, ACOT1 has also been shown to be involved in the regulation of the immune response, which is a critical function of the brain. This protein has been shown to interact with the immune receptor PD-L1 and may play a role in the regulation of immune cell activity in the brain.

ACOT1 is also a potential drug target for Alzheimer's disease. Studies have shown that inhibiting ACOT1 can significantly reduce the formation of neurofibrillary tangles in animal models of Alzheimer's disease. Additionally, inhibiting ACOT1 has been shown to improve memory and other cognitive functions in animal models of Alzheimer's disease.

In conclusion, ACOT1 is a protein that is involved in the development and progression of Alzheimer's disease. Its involvement in the formation of neurofibrillary tangles and the regulation of neurotransmitter and immune cell activity suggests that it may be a useful target for the development of new treatments for Alzheimer's disease. Further research is needed to fully understand the role of ACOT1 in the development and progression of Alzheimer's disease, as well as its potential as a drug target.

Protein Name: Acyl-CoA Thioesterase 1

Functions: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20)

The "ACOT1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ACOT1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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