PLA2G10: A Protein Involved in Cellular Signaling and Pain (G8399)

Target Name: PLA2G10

NCBI ID: G8399

PLA2G10

PLA2G10: A Protein Involved in Cellular Signaling and Pain

PLA2G10 (GXPLA2) is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and kidney. It is a member of the G protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play a crucial role in cellular signaling.

PLA2G10 is known for its role in the regulation of inflammation and cellular signaling. It is a potent inhibitor of the hyperactivated state of the transcription factor Nrf2, which is a key transcription factor that regulates the expression of many genes involved in the inflammatory response.

The Nrf2 gene is well-established as a major regulator of cellular stress responses, and it is known to play a role in a variety of cellular processes, including stress signaling, DNA damage repair, and neurodegeneration. The Nrf2 gene has also been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

PLA2G10 is expressed in a variety of tissues and organs, including the brain, heart, liver, and kidney. It is primarily expressed in the brain, where it is involved in the regulation of neural stem cell (NSC) proliferation and differentiation. PLA2G10 has has been shown to play a role in the regulation of NSC survival and proliferation, and it is a potential drug target for the treatment of a variety of neurological and psychiatric disorders.

In addition to its role in the regulation of NSC survival and proliferation, PLA2G10 is also involved in the regulation of cellular signaling pathways that are involved in inflammation and pain. It is a potent inhibitor of the hyperactivated state of the transcription factor Nrf2, which is a key transcription factor that regulates the expression of many genes involved in the inflammatory response.

PLA2G10 has been shown to play a role in the regulation of inflammation and cellular signaling pathways that are involved in pain and neurodegeneration. It is a potential drug target for the treatment of a variety of pain and neurodegenerative disorders.

In conclusion, PLA2G10 is a protein that is involved in a variety of cellular processes that are important for the regulation of inflammation and signaling pathways that are involved in pain and neurodegeneration. As a potential drug target, PLA2G10 is a promising target for the treatment of a variety of disorders, including pain and neurodegenerative diseases. Further research is needed to fully understand the role of PLA2G10 in cellular signaling pathways and its potential as a drug target.

Protein Name: Phospholipase A2 Group X

Functions: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:9188469, PubMed:12021277). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls (PubMed:12359733, PubMed:12021277). Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles (PubMed:12021277). Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (PubMed:12021277). Efficiently hydrolyzes and inactivates platelet activating factor (PAF), a potent lipid mediator present in oxidized LDL (PubMed:16962371). May act in an autocrine and paracrine manner. Secreted by lung epithelium, targets membrane phospholipids of infiltrating eosinophils, releasing arachidonate and boosting eicosanoid and cysteinyl leukotriene synthesis involved in airway inflammatory response (By similarity). Secreted by gut epithelium, hydrolyzes dietary and biliary phosphatidylcholines in the gastrointestinal lumen (By similarity). Plays a stem cell regulator role in colon epithelium. Within intracellular compartment, mediates Paneth-like cell differentiation and its stem cell supporting functions by inhibiting the Wnt signaling pathway in intestinal stem cell (ISC). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ISCs and tissue regeneration (By similarity). May participate in hair follicle morphogenesis by regulating phosphatidylethanolamines metabolism at the outermost epithelial layer and facilitating melanin synthesis (By similarity). By releasing lysophosphatidylcholines (LPCs) at sperm acrosome, controls sperm cell capacitation, acrosome reaction and overall fertility (By similarity). May promote neurite outgrowth in neuron fibers involved in nociception (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria (PubMed:12359733). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). In pulmonary epithelium, may contribute to host defense response against adenoviral infection. Prevents adenovirus entry into host cells by hydrolyzing host cell plasma membrane, releasing C16:0 LPCs that inhibit virus-mediated membrane fusion and viral infection. Likely prevents adenoviral entry into the endosomes of host cells (PubMed:16146426). May play a role in maturation and activation of innate immune cells including macrophages, group 2 innate lymphoid cells and mast cells (By similarity)

The "PLA2G10 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PLA2G10 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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