PLA2G4E: Regulating Inflammation and Tissue Development (G123745)

Target Name: PLA2G4E

NCBI ID: G123745

PLA2G4E

PLA2G4E: Regulating Inflammation and Tissue Development

PLA2G4E, also known as cPLA2-epsilon, is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the PLA2 family of proteins, which are involved in the regulation of cellular signaling pathways. One of the key functions of PLA2G4E is to activate the 5-lipoxygenase (5-LO) pathway, which is involved in the production of pro-inflammatory compounds.

The 5-LO pathway is a critical pathway that is involved in the regulation of inflammation and immune responses. When the body is exposed to an infection or injury, the 5-LO pathway is activated to produce pro-inflammatory cytokines and chemokines, which help to recruit and activate immune cells to fight off the infection or injury. However, if the immune response is excessive or prolonged, it can lead to the production of pro-inflammatory compounds that can cause tissue damage and inflammation.

PLA2G4E is involved in the regulation of the 5-LO pathway by activating its catalytic activity. This involves the addition of a phosphate group to the protein, which allows it to interact with and activate the 5-LO enzyme. OncePLA2G4E is activated, it can help to regulate the production of pro-inflammatory cytokines and chemokines, thereby limiting the amount of inflammation that occurs during an immune response.

PLA2G4E is also involved in the regulation of cellular signaling pathways that are important for brain development and function. For example, PLA2G4E has been shown to be involved in the regulation of neurogenesis, which is the process by which new neurons are produced in the brain. PLA2G4E has been shown to play a key role in the production of neurogenic progeny, which are cells that have the ability to generate new neurons and replace damaged or lost cells.

In addition to its role in the regulation of inflammation and neurogenesis, PLA2G4E is also involved in the regulation of cellular signaling pathways that are important for heart and kidney function. For example, PLA2G4E has been shown to be involved in the regulation of fibrosis, which is the process by which tissues become stiff and fibrotic. PLA2G4E has been shown to play a key role in the regulation of fibrosis by promoting the production of extracellular matrix (ECM) components and by inhibiting the production of pro-inflammatory cytokines.

PLA2G4E is also involved in the regulation of cellular signaling pathways that are important for the development and maintenance of tissues. For example, PLA2G4E has been shown to be involved in the regulation of cell cycle progression, which is the process by which cells grow, divide, and replicate their genetic material. PLA2G4E has been shown to play a key role in the regulation of cell cycle progression by promoting the production of pro-inflammatory cytokines and by inhibiting the production of anti-inflammatory cytokines.

In conclusion, PLA2G4E is a protein that is involved in the regulation of various cellular signaling pathways that are important for inflammation, neurogenesis, heart and kidney function, and tissue development and maintenance. As a drug target or biomarker, PLA2G4E may be a useful target for the development of new treatments for a variety of diseases, including autoimmune diseases, cancer, and cardiovascular disease. Further research is needed to fully understand the role of PLA2G4E in these processes and to develop new treatments based on this protein.

Protein Name: Phospholipase A2 Group IVE

Functions: Calcium-dependent N-acyltransferase involved in the biosynthesis of N-acyl ethanolamines (NAEs) in the brain (PubMed:29447909). Transfers the sn-1 fatty acyl chain of phosphatidylcholine (fatty acyl donor) to the amine group of phosphatidylethanolamine (fatty acyl acceptor) to generate N-acyl phosphatidylethanolamine (NAPE). Similarly can use plasmenylethanolamine as a fatty acyl acceptor to form N-acyl plasmenylethanolamine (N-Acyl-PlsEt). Both NAPE and N-Acyl-PlsEt can serve as precursors of bioactive NAEs like N-arachidonoyl phosphatidylethanolamine also called anandamide (PubMed:29447909, PubMed:30517655). Has weak phospholipase A2 and lysophospholipase activities (By similarity). Regulates intracellular membrane trafficking that requires modulation of membrane curvature as it occurs by enrichment in lysophospholipids. Promotes tubule formation involved in clathrin-independent endocytotic trafficking and cargo recycling (By similarity)

The "PLA2G4E Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PLA2G4E comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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