PLA2G12A: A Potential Drug Target and Biomarker (G81579)

Target Name: PLA2G12A

NCBI ID: G81579

PLA2G12A

PLA2G12A: A Potential Drug Target and Biomarker

PLA2G12A, also known as Group XII secreted phospholipase A2 (SPLA2A), is a protein that is expressed in various tissues throughout the body, including the brain, heart, and blood vessels. It is a member of the PLA2 family of enzymes, which are involved in the process of phosphatidylinositol synthesis.

PLA2G12A is characterized by its catalytic active site, which is located in the N-terminus of the protein. This site is responsible for the formation of the phosphatidylinositol molecule, which is a key component of various cell signaling pathways. In addition to its role in Phospholipid synthesis, PLA2G12A has also been shown to play a role in the regulation of cellular signaling pathways, including the regulation of cell adhesion, angiogenesis, and inflammation.

Due to its unique structure and the involvement in multiple cellular processes, PLA2G12A has been identified as a potential drug target. Studies have shown that PLA2G12A can be inhibited by various small molecules, including inhibitors of the PI3K/Akt signaling pathway. This suggests that PLA2G12A may be a useful target for the treatment of various diseases that are characterized by the over-activity of this pathway, such as cancer, neurodegenerative diseases, and autoimmune disorders.

In addition to its potential as a drug target, PLA2G12A has also been shown to be a useful biomarker for the diagnosis and monitoring of various diseases. For example, PLA2G12A has been used as a biomarker for the detection of cancer, both in terms of its expression levels and its potential as a therapeutic target. Additionally, PLA2G12A has been used as a biomarker for a variety of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

PLA2G12A is also a good candidate as a biomarker for monitoring the effectiveness of anti-inflammatory drugs. Its ability to regulate the production of pro-inflammatory cytokines and its role in the regulation of cellular signaling pathways make it an attractive candidate for the study of the effects of anti-inflammatory drugs on various diseases.

In conclusion, PLA2G12A is a unique protein that plays a critical role in the regulation of various cellular processes. Its potential as a drug target and biomarker make it an attractive candidate for further research and development. Further studies are needed to fully understand its role in the regulation of cellular processes and its potential as a therapeutic agent.

Protein Name: Phospholipase A2 Group XIIA

Functions: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine

The "PLA2G12A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PLA2G12A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets